Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDK7 [nucleoplasm]
Stable Identifier
R-HSA-69218
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk7, Cell division protein kinase 7 (EC 2.7.1.-) (CDK-activating kinase) (CAK)(TFIIH) (basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15)(STK1)(CAK1), Cell division protein kinase 7 , CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit, 39 kDa protein kinase, P39 Mo15, STK1, CAK1
Locations in the PathwayBrowser for interactor UniProt:P32780 GTF2H1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
CDK7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50613 CDK7
Gene Names
CDK7, CAK, CAK1, CDKN7, MO15, STK1
Chain
initiator methionine:, chain:2-346
Reference Genes
BioGPS Gene:1022 CDK7
COSMIC (genes):CDK7 CDK7
CTD Gene:1022 CDK7
dbSNP Gene:1022 CDK7
ENSEMBL:ENSG00000134058 CDK7
ENSEMBL_homo_sapiens_GENE:ENSG00000134058.12 CDK7
ENSEMBL_homo_sapiens_GENE:ENSG00000277273.5 CDK7
HGNC:1778 CDK7
KEGG Gene (Homo sapiens):1022 CDK7
Monarch:1022 CDK7
NCBI Gene:1022 CDK7
OMIM:601955 CDK7
UCSC:P50613 CDK7
Reference Transcript
RefSeq:NM_001324069.1 CDK7
RefSeq:NM_001324071.1 CDK7
RefSeq:NM_001324070.1 CDK7
RefSeq:NM_001799.3 CDK7
RefSeq:NM_001324077.1 CDK7
Other Identifiers
1022
11717845_a_at
16985637
1969_s_at
211297_PM_s_at
211297_s_at
2813483
2813484
2813486
2813490
2813492
2813493
2813498
2813499
2813500
2813503
2813505
2813506
2813507
2813508
33317_at
8105862
8177462
A_23_P133585
GE79229
GO:0000079
GO:0000166
GO:0000278
GO:0000439
GO:0001650
GO:0001673
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005675
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0006281
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006367
GO:0006468
GO:0006974
GO:0007049
GO:0008094
GO:0008353
GO:0016073
GO:0016301
GO:0016310
GO:0016740
GO:0019907
GO:0036211
GO:0042795
GO:0043226
GO:0045944
GO:0048471
GO:0050821
GO:0051301
GO:0051726
GO:0070516
GO:0070985
GO:0106310
GO:0140096
GO:0140097
GO:0140657
GO:2000045
HMNXSV003054204
ILMN_1778917
L20320_at
PH_hs_0027953
TC05000301.hg
g348242_3p_a_at
Participates
as an input of
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
as a component of
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
CAK [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of CDK7 [nucleoplasm]
(Plasmodium falciparum)
CDK7 [nucleoplasm]
(Bos taurus)
CDK7 [nucleoplasm]
(Caenorhabditis elegans)
CDK7 [nucleoplasm]
(Canis familiaris)
CDK7 [nucleoplasm]
(Danio rerio)
CDK7 [nucleoplasm]
(Dictyostelium discoideum)
CDK7 [nucleoplasm]
(Drosophila melanogaster)
CDK7 [nucleoplasm]
(Gallus gallus)
CDK7 [nucleoplasm]
(Mus musculus)
CDK7 [nucleoplasm]
(Rattus norvegicus)
CDK7 [nucleoplasm]
(Saccharomyces cerevisiae)
CDK7 [nucleoplasm]
(Schizosaccharomyces pombe)
CDK7 [nucleoplasm]
(Sus scrofa)
CDK7 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001790.1
,
NP_001310999.1
,
NP_001311000.1
,
NP_001311006.1
,
NP_001310998.1
ZINC - World Drugs
CDK7_HUMAN
Guide to Pharmacology - Targets
1979
OpenTargets
ENSG00000134058
ZINC - FDA approved
CDK7_HUMAN
ZINC - Substances
CDK7_HUMAN
ZINC - Biogenic
CDK7_HUMAN
ZINC target
P50613
PRO
P50613
PDB
8P73
,
6XD3
,
8GXQ
,
8PYR
,
7EGB
,
7ENC
,
8P72
,
8P75
,
8P6W
,
8BYQ
,
7B5O
,
8P7L
,
8GXS
,
7EGC
,
8P6V
,
8P4Z
,
8P74
,
8P77
,
6XBZ
,
8P6Y
,
8ORM
,
7NVR
,
7LBM
,
8P6X
,
7B5Q
,
8P76
,
8P71
,
7ENA
,
8P79
,
6O9L
,
1UA2
,
8BVW
,
8P6Z
,
8P78
,
8PLZ
,
8P70
ZINC - Investigational
CDK7_HUMAN
IntEnz
2.7.11.23
HPA
ENSG00000134058-CDK7
GeneCards
P50613
Ensembl
ENSG00000277273
,
ENSP00000479116
,
ENSP00000256443
,
ENSG00000134058
,
ENST00000615305
,
ENST00000256443
Pharos - Targets
P50613
ZINC - Predictions - Purchasable
CDK7_HUMAN
HMDB Protein
HMDBP01388
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51946 CCNH
1
CCNH [nucleoplasm]
(R-HSA-69220)
0.943
19
UniProt:P51948 MNAT1
1
MNAT1 [nucleoplasm]
(R-HSA-59012)
0.899
15
UniProt:P18074 ERCC2
2
ERCC2 [cytosol]
(R-HSA-2564770)
ERCC2 [nucleoplasm]
(R-HSA-67443)
0.848
11
UniProt:P19447 ERCC3
1
ERCC3 [nucleoplasm]
(R-HSA-67439)
0.848
9
UniProt:P32780 GTF2H1
1
GTF2H1 [nucleoplasm]
(R-HSA-65912)
0.816
8
UniProt:Q6ZYL4 GTF2H5
1
GTF2H5 [nucleoplasm]
(R-HSA-5688446)
0.802
8
UniProt:Q92759 GTF2H4
1
GTF2H4 [nucleoplasm]
(R-HSA-65918)
0.802
8
UniProt:P28715 ERCC5
1
ERCC5 [nucleoplasm]
(R-HSA-67447)
0.802
8
UniProt:Q13889 GTF2H3
1
GTF2H3 [nucleoplasm]
(R-HSA-65916)
0.745
7
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.713
3
UniProt:Q13888 GTF2H2
1
GTF2H2 [nucleoplasm]
(R-HSA-65914)
0.671
9
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.669
4
UniProt:Q6P1K8 T2H2L
0.643
3
UniProt:Q96SB4 SRPK1
2
SRPK1 [nucleoplasm]
(R-HSA-9821984)
SRPK1 [cytosol]
(R-HSA-9729349)
0.59
2
UniProt:P78362 SRPK2
1
SRPK2 [cytosol]
(R-HSA-9729332)
0.59
2
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.569
5
UniProt:Q58FG1 HS904
0.527
3
UniProt:Q58FG0 HS905
0.527
3
UniProt:Q58FF6 H90B4
0.527
3
UniProt:Q13137 CACO2
0.527
2
UniProt:Q8IZL9 CDK20
0.527
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.527
2
UniProt:P24864 CCNE1
3
CCNE1 [nucleoplasm]
(R-HSA-68363)
CCNE1 [cytosol]
(R-HSA-157443)
Unfolded CCNE1 [cytosol]
(R-HSA-6813836)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.527
3
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.527
2
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.527
2
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.527
3
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.527
2
UniProt:P46013 KI67
0.483
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text