Reactome | CDK7 [nucleoplasm]

CDK7 [nucleoplasm]

Stable Identifier

R-HSA-69218

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cdk7, Cell division protein kinase 7 (EC 2.7.1.-) (CDK-activating kinase) (CAK)(TFIIH) (basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15)(STK1)(CAK1), Cell division protein kinase 7 , CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit, 39 kDa protein kinase, P39 Mo15, STK1, CAK1

Locations in the PathwayBrowser for interactor UniProt:Q86X55 CARM1

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External Reference Information

External Reference

UniProt:P50613 CDK7

Gene Names

CDK7, CAK, CAK1, CDKN7, MO15, STK1

Chain

initiator methionine:, chain:2-346

Reference Genes

BioGPS Gene:1022 CDK7

COSMIC (genes):CDK7 CDK7

CTD Gene:1022 CDK7

dbSNP Gene:1022 CDK7

ENSEMBL:ENSG00000134058 CDK7

HGNC:1778 CDK7

KEGG:hsa:1022 CDK7

Monarch:1022 CDK7

NCBI Gene:1022 CDK7

OMIM:601955 CDK7

UCSC:P50613 CDK7

Reference Transcript

Other Identifiers

1022

11717845_a_at

16985637

1969_s_at

211297_PM_s_at

211297_s_at

2813483

2813484

2813485

2813486

2813489

2813490

2813492

2813493

2813494

2813495

2813496

2813498

2813499

2813500

2813503

2813505

2813506

2813507

2813508

33317_at

8105862

8177462

A_14_P115402

A_14_P126498

A_23_P133585

GE79229

GO:0000307

GO:0000439

GO:0001650

GO:0001673

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005675

GO:0005737

GO:0005829

GO:0005886

GO:0006281

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006367

GO:0006468

GO:0008094

GO:0008353

GO:0016073

GO:0016301

GO:0016740

GO:0042795

GO:0043226

GO:0045944

GO:0048471

GO:0050821

GO:0051301

GO:0051726

GO:0070516

GO:0070985

GO:0106310

GO:0140096

GO:0140097

GO:0140657

GO:2000045

HMNXSV003054204

ILMN_1778917

L20320_at

PH_hs_0027953

TC05000301.hg

g348242_3p_a_at

Participates

as an input of

General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)

as a component of

Inferred To

Ghost homologue of CDK7 [nucleoplasm] (Plasmodium falciparum)

CDK7 [nucleoplasm] (Bos taurus)

CDK7 [nucleoplasm] (Caenorhabditis elegans)

CDK7 [nucleoplasm] (Canis familiaris)

CDK7 [nucleoplasm] (Danio rerio)

CDK7 [nucleoplasm] (Dictyostelium discoideum)

CDK7 [nucleoplasm] (Drosophila melanogaster)

CDK7 [nucleoplasm] (Gallus gallus)

CDK7 [nucleoplasm] (Mus musculus)

CDK7 [nucleoplasm] (Rattus norvegicus)

CDK7 [nucleoplasm] (Saccharomyces cerevisiae)

CDK7 [nucleoplasm] (Schizosaccharomyces pombe)

CDK7 [nucleoplasm] (Sus scrofa)

CDK7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001311000.1, NP_001790.1, NP_001310998.1, NP_001310999.1, NP_001311006.1

Guide to Pharmacology - Targets

1979

OpenTargets

ENSG00000134058

ENSEMBL

ENSP00000479116, ENSG00000277273, ENST00000615305, ENSG00000134058, ENSP00000256443, ENST00000256443

ZINC - FDA approved

CDK7_HUMAN

ZINC - Substances

CDK7_HUMAN

ZINC - Biogenic

CDK7_HUMAN

ZINC target

P50613

PRO

P50613

GlyGen

P50613

PDB

8R9O, 6XD3, 8P7L, 8ORM, 7NVR, 8P6Z, 8P76, 8P74, 8P4Z, 1UA2, 8BYQ, 8R9S, 8R9U, 8GXS, 8GXQ, 7EGC, 7EGB, 8BVW, 7LBM, 6O9L, 8PLZ, 8P6X, 7B5O, 8P79, 8R99, 8P6V, 8P71, 8P77, 7B5Q, 7ENC, 7ENA, 8R9B, 6XBZ, 8P73, 8P75, 8P70, 8P6Y, 8P72, 8PYR, 8R9A, 8P6W, 8P78

ZINC - Investigational

CDK7_HUMAN

IntEnz

2.7.11.23

HPA

ENSG00000134058-CDK7

GeneCards

CDK7

Pharos - Targets

P50613

ZINC - Predictions - Purchasable

CDK7_HUMAN

HMDB Protein

HMDBP01388

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.943	19
UniProt:P51948 MNAT1	1	MNAT1 [nucleoplasm] (R-HSA-59012)	0.899	15
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.848	9
UniProt:P18074 ERCC2	2	ERCC2 [nucleoplasm] (R-HSA-67443) ERCC2 [cytosol] (R-HSA-2564770)	0.848	11
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.816	8
UniProt:Q92759 GTF2H4	1	GTF2H4 [nucleoplasm] (R-HSA-65918)	0.802	8
UniProt:P28715 ERCC5	1	ERCC5 [nucleoplasm] (R-HSA-67447)	0.802	8
UniProt:Q6ZYL4 GTF2H5	1	GTF2H5 [nucleoplasm] (R-HSA-5688446)	0.802	8
UniProt:Q13889 GTF2H3	1	GTF2H3 [nucleoplasm] (R-HSA-65916)	0.745	7
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.713	3
UniProt:Q13888 GTF2H2	1	GTF2H2 [nucleoplasm] (R-HSA-65914)	0.671	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.669	4
UniProt:Q6P1K8 T2H2L			0.643	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.59	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.59	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.569	5
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.527	2
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.527	3
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.527	2
UniProt:Q8IZL9 CDK20			0.527	3
UniProt:Q13137 CACO2			0.527	2
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.527	2
UniProt:P24864 CCNE1	3	CCNE1 [cytosol] (R-HSA-157443) CCNE1 [nucleoplasm] (R-HSA-68363) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.527	2
UniProt:Q58FF6 H90B4			0.527	3
UniProt:Q58FG0 HS905			0.527	3
UniProt:Q58FG1 HS904			0.527	3
UniProt:P46013 KI67			0.483	3

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