Reactome | CCNH [nucleoplasm]

CCNH [nucleoplasm]

Stable Identifier

R-HSA-69220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin H, MO15-associated protein, p37, p34

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - Recruitment of XPA and release of CAK (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - ERCC5 and RPA bind TC-NER site (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
    - Formation of TC-NER Pre-Incision Complex (Homo sapiens)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Homo sapiens)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - Assembly of the pre-incision complex in TC-NER (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - ERCC6 binds stalled RNA Pol II (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
    - Recovery of RNA synthesis after TC-NER (Homo sapiens)
      - TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)
      - TFIIH [nucleoplasm] (Homo sapiens)
        
        CAK [nucleoplasm] (Homo sapiens)
        
        CCNH [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51946 CCNH

Gene Names

CCNH

Chain

chain:1-323

Reference Genes

BioGPS Gene:902 CCNH

COSMIC (genes):CCNH CCNH

CTD Gene:902 CCNH

dbSNP Gene:902 CCNH

ENSEMBL:ENSG00000134480 CCNH

HGNC:1594 CCNH

KEGG:hsa:902 CCNH

Monarch:902 CCNH

NCBI Gene:902 CCNH

OMIM:601953 CCNH

UCSC:P51946 CCNH

Reference Transcript

RefSeq:NM_001239.3 CCNH

Other Identifiers

11720054_a_at

16997860

1924_at

204093_3p_at

204093_PM_at

204093_at

2865861

2865862

2865863

2865864

2865877

2865878

2865879

2865880

2865881

2865882

2865883

2865884

2865885

2865886

2865887

2865888

2865889

2865890

2865892

2865893

2865894

2865895

2865896

2865897

2865898

2865899

2865900

2865901

2865902

2865903

2865904

36086_at

71416_at

8113010

902

A_23_P30338

A_33_P3708364

GE62742

GO:0000307

GO:0000439

GO:0005515

GO:0005634

GO:0005654

GO:0005675

GO:0006351

GO:0006355

GO:0006357

GO:0006367

GO:0016251

GO:0016538

GO:0043226

GO:0050821

GO:0070516

GO:0070985

GO:0098772

GO:0140223

GO:2000045

HMNXSV003011654

HMNXSV003025305

HMNXSV003056958

ILMN_1742250

ILMN_2187830

PH_hs_0000062

TC05001570.hg

U11791_at

g4502622_3p_at

g4502622_3p_s_at

Participates

as a component of

CAK [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of CCNH [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of CCNH [nucleoplasm] (Danio rerio)

Ghost homologue of CCNH [nucleoplasm] (Plasmodium falciparum)

CycH [nucleoplasm] (Drosophila melanogaster)

cycH [nucleoplasm] (Dictyostelium discoideum)

Ccnh [nucleoplasm] (Mus musculus)

Ccnh [nucleoplasm] (Rattus norvegicus)

ccnh [nucleoplasm] (Xenopus tropicalis)

CCNH [nucleoplasm] (Bos taurus)

CCNH [nucleoplasm] (Canis familiaris)

CCNH [nucleoplasm] (Gallus gallus)

CCNH [nucleoplasm] (Sus scrofa)

mcs2 [nucleoplasm] (Schizosaccharomyces pombe)

CCL1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001230.1

OpenTargets

ENSG00000134480

ENSEMBL

ENSP00000256897, ENST00000256897, ENSG00000134480

HPA

ENSG00000134480-CCNH

GeneCards

CCNH

PRO

P51946

Pharos - Targets

P51946

GlyGen

P51946

PDB

6XD3, 8ORM, 7NVR, 8P6Z, 8P74, 8P76, 1KXU, 8BYQ, 8GXS, 8GXQ, 7EGC, 7EGB, 8BVW, 7LBM, 6O9L, 8P6X, 8PLZ, 8P79, 7B5O, 8P6V, 8P77, 8P71, 7B5Q, 7ENA, 7ENC, 6XBZ, 1JKW, 8P75, 8P73, 8P6Y, 8P70, 8P72, 8PYR, 8P6W, 8P78

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.943	19
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.87	9
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.818	6
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.781	9
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.666	4
UniProt:Q9Y216 MTMR7	1	MTMR7 [cytosol] (R-HSA-1604650)	0.666	6
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.556	5
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q15669 RHOH	1	RHOH [plasma membrane] (R-HSA-194859)	0.556	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.544	2
UniProt:P28715 ERCC5	1	ERCC5 [nucleoplasm] (R-HSA-67447)	0.527	2

Cite Us!