Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions. The G2/M transition is regulated through the phosphorylation of nuclear lamins and histones (reviewed in Sefton, 2001).The two B-type cyclins localize to different regions within the cell and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytoplasmic during interphase and translocates into the nucleus at the onset of mitosis (Jackman et al., 1995; Hagting et al., 1999). Cyclin B2 colocalizes with the Golgi apparatus and contributes to its fragmentation during mitosis (Jackman et al., 1995; Draviam et al., 2001).
Jackman, M, Firth, M, Pines, J
Hagting, A, Jackman, M, Simpson, K, Pines, J
Sefton, BM
Draviam, VM, Orrechia, S, Lowe, M, Pardi, R, Pines, J
Bellanger, S, de Gramont, A, Sobczak-Thépot, J
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