Reactome | Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A/B1/B2 associated events during G2/M transition

Stable Identifier

R-HSA-69273

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

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Summation

Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions. The G2/M transition is regulated through the phosphorylation of nuclear lamins and histones (reviewed in Sefton, 2001).
The two B-type cyclins localize to different regions within the cell and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytoplasmic during interphase and translocates into the nucleus at the onset of mitosis (Jackman et al., 1995; Hagting et al., 1999). Cyclin B2 colocalizes with the Golgi apparatus and contributes to its fragmentation during mitosis (Jackman et al., 1995; Draviam et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
11238451	The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus Draviam, VM, Orrechia, S, Lowe, M, Pardi, R, Pines, J	J Cell Biol	2001
17533373	Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2 Bellanger, S, de Gramont, A, Sobczak-Th�pot, J	Oncogene	2007
18228324	Overview of protein phosphorylation Sefton, BM	Curr Protoc Cell Biol	2001
7737117	Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus Jackman, M, Firth, M, Pines, J	EMBO J	1995
10395539	Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal Hagting, A, Jackman, M, Simpson, K, Pines, J	Curr Biol	1999