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G2/M DNA damage checkpoint
Stable Identifier
R-HSA-69473
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
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Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation. The different DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). Failure of the G2 DNA damage checkpoint leads to catastrophic attempts to segregate unrepaired chromosomes.
Participants
Events
Recruitment and activation of Chk1
(Homo sapiens)
CHEK2 is recruited to DNA DSBs
(Homo sapiens)
Phosphorylation and activation of CHEK2 by ATM
(Homo sapiens)
p-T68-CHEK2 dimerizes
(Homo sapiens)
p-T68-CHEK2 autophosphorylates
(Homo sapiens)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
(Homo sapiens)
ATR phosphorylates TP53
(Homo sapiens)
CHEK1 phosphorylates TP53
(Homo sapiens)
Participates
as an event of
G2/M Checkpoints (Homo sapiens)
Orthologous Events
G2/M DNA damage checkpoint (Bos taurus)
G2/M DNA damage checkpoint (Caenorhabditis elegans)
G2/M DNA damage checkpoint (Canis familiaris)
G2/M DNA damage checkpoint (Danio rerio)
G2/M DNA damage checkpoint (Dictyostelium discoideum)
G2/M DNA damage checkpoint (Drosophila melanogaster)
G2/M DNA damage checkpoint (Gallus gallus)
G2/M DNA damage checkpoint (Mus musculus)
G2/M DNA damage checkpoint (Plasmodium falciparum)
G2/M DNA damage checkpoint (Rattus norvegicus)
G2/M DNA damage checkpoint (Saccharomyces cerevisiae)
G2/M DNA damage checkpoint (Schizosaccharomyces pombe)
G2/M DNA damage checkpoint (Sus scrofa)
G2/M DNA damage checkpoint (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000939
Created
Walworth, N (2003-06-05)
O'Donnell, M (2003-06-05)
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