Transcriptional activation of p53 responsive genes

Stable Identifier
R-HSA-69560
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

p53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that mediate G1/S progression, resulting in lack of phosphorylation of Rb, E2F sequestration and cell cycle arrest at the G1/S transition. Mice with a homozygous deletion of p21 gene are deficient in their ability to undergo a G1/S arrest in response to DNA damage (Deng et al, 1995).

Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

el-Deiry, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, Trent, JM, Lin, D, Mercer, WE, Kinzler, KW, Vogelstein, B

Cell 1993
8259214 p21 is a universal inhibitor of cyclin kinases.

Xiong, Y, Hannon, GJ, Zhang, H, Casso, D, Kobayashi, R, Beach, D

Nature 1994
8242751 The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Harper, JW, Adami, GR, Wei, N, Keyomarsi, K, Elledge, SJ

Cell 1993
7664346 Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.

Deng, C, Zhang, P, Harper, JW, Elledge, SJ, Leder, P

Cell 1995
Participants
Participant Of
Orthologous Events