Reactome: A Curated Pathway Database

Inactivation of Cyclin E:Cdk2 complexes by p27/p21

Stable Identifier
R-HSA-69562
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

During G1, the activity of cyclin-dependent kinases (CDKs) is controlled by the CDK inhibitors (CKIs) CDKN1A (p21) and CDKN1B (p27), thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 2006). The efficient recognition and ubiquitination of p27 by the SCF (Skp2) complex requires the formation of a trimeric complex containing p27 and cyclin E/A:Cdk2.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm] CDKN1A,CDKN1B [nucleoplasm] cyclin-dependent protein serine/threonine kinase inhibitor activity (0004861)
Orthologous Events