p53-Dependent G1/S DNA damage checkpoint

Stable Identifier
R-HSA-69580
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbitz et al, 1992). P53 is rapidly induced in response to damaged DNA. A number of kinases, phosphatases, histone acetylases and ubiquitin-conjugating enzymes regulate the stability as well as transcriptional activity of p53 after DNA damage.

Literature References
PubMed ID Title Journal Year
1323840 Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Kuerbitz, SJ, Plunkett, BS, Walsh, WV, Kastan, MB

Proc Natl Acad Sci U S A 1992
Participants
Participant Of
Orthologous Events
Authored
Created