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Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Stable Identifier
R-HSA-69601
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
p53-Independent DNA Damage Response (Homo sapiens)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
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cdc25A protein is degraded by the ubiquitin-proteasome machinery in both terminally differentiating and cycling cells (Bernardi et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
10828887
Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation
Bernardi, R
,
Hoffman, B
,
Liebermann, DA
Oncogene
2000
Participants
Events
Phosphorylation of Cdc25A at Ser-123 by Chk2
(Homo sapiens)
Ubiquitination of phosphorylated Cdc25A
(Homo sapiens)
Proteolytic degradation of ubiquitinated-Cdc25A
(Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk1
(Homo sapiens)
Participates
as an event of
p53-Independent DNA Damage Response (Homo sapiens)
Orthologous Events
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Bos taurus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Caenorhabditis elegans)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Dictyostelium discoideum)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Gallus gallus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Rattus norvegicus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Saccharomyces cerevisiae)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Schizosaccharomyces pombe)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Sus scrofa)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Xenopus tropicalis)
Created
Hoffmann, I (2003-06-05)
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