Phosphorylation of Cdc25A at Ser-123 by Chk1

Stable Identifier
R-HSA-69604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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Detection of DNA damage caused by ionizing radiation results in the phosphorylation of Cdc25A at Ser-123 by Chk1, inhibiting Cdc25A.
Literature References
PubMed ID Title Journal Year
12399544 Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Piwnica-Worms, H, Zhao, H, Watkins, JL

Proc Natl Acad Sci U S A 2002
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]

Orthologous Events
Created
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