Phosphorylation of Cdc25A at Ser-123 by Chk2

Stable Identifier
R-HSA-69608
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Detection of DNA damage caused by ionizing radiation results in the phosphorylation of Cdc25A at Ser-123 by Chk2 (Mailand et al. 2001).

Literature References
PubMed ID Title Journal Year
11298456 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

Mailand, N, SyljuÄsen, RG, Lukas, J

Nature 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Created