p53-Independent DNA Damage Response

Stable Identifier
R-HSA-69610
Type
Pathway
Species
Homo sapiens
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In response to DNA damage due to exposure to ultraviolet light or to ionizing radiation, Cdc25A is phosphorylated by Chk1 or Chk2. The phosphorylation of Cdc25A at ser-123, in response to DNA damage from ionizing radiation is a signal for ubiquitination and subsequent degradation of Cdc25A. The destruction of Cdc25A prevents the normal G1/S transition. Cdc25A is required for the activation of the Cyclin E:Cdk2 complexes via dephosphorylation.

Chk1 is activated in response to DNA damage due to uv light. However, the phosphorylation occurs at a different site.

Literature References
PubMed ID Title Journal Year
11298456 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

Mailand, N, SyljuÄsen, RG, Lukas, J

Nature 2001
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Orthologous Events
Created