Reactome | p-T177-CDK6 [nucleoplasm]

p-T177-CDK6 [nucleoplasm]

Stable Identifier

R-HSA-69628

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Cdk6, Cell division protein kinase 6 , Serine/threonine protein kinase PLSTIRE

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1-G1/S phases (Homo sapiens)
    - G1 Phase (Homo sapiens)
      - Cyclin D associated events in G1 (Homo sapiens)
        
        CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00534 CDK6

Gene Names

CDK6, CDKN6

Chain

chain:1-326

Reference Genes

BioGPS Gene:1021 CDK6

COSMIC (genes):CDK6 CDK6

CTD Gene:1021 CDK6

dbSNP Gene:1021 CDK6

ENSEMBL:ENSG00000105810 CDK6

HGNC:1777 CDK6

KEGG Gene (Homo sapiens):1021 CDK6

Monarch:1021 CDK6

NCBI Gene:1021 CDK6

OMIM:603368 CDK6

UCSC:Q00534 CDK6

Reference Transcript

Other Identifiers

0002510520

0103850332

1021

11723241_at

11723242_at

11723243_at

11723244_at

1207_at

17059756

1BI7

1BI8

1BLX

1G3N

1JOW

1XO2

207143_at

224847_at

224848_at

224851_at

231198_at

235287_at

243000_at

2637

2EUF

2F2C

3061320

3061321

3061322

3061323

3061324

3061325

3061326

3061327

3061328

3061329

3061330

3061331

3061336

3061348

3061349

3061360

3061361

3061362

3061385

3061398

3061399

3061400

3061402

3061406

3061407

3NUP

3NUX

41545_at

4363

4AUA

4EZ5

4TTH

57070_at

5L2I

5L2S

5L2T

65733_at

69864_at

75209_r_at

75491_at

8140955

83673_at

89442_at

91819_at

A_23_P168651

A_24_P166663

AAH52264

AAM76970

AC000065

AC004011

AC004128

AK313491

AY128534

BAG36273

BC052264

CAA47008

CAB004363

CCDS5628

CDK6

CDK6-201

CDK6-202

CH236949

CH471091

EAL24146

EAW76827

ENSG00000105810

ENSP00000265734

ENSP00000397087

ENST00000265734

ENST00000265734.8

ENST00000424848

ENST00000424848.2

EntrezGene:1021

EntrezGene:CDK6

g4502740_3p_at

GE80452

GE88785

GO:0000082

GO:0000122

GO:0000166

GO:0000278

GO:0000307

GO:0001726

GO:0001954

GO:0002244

GO:0002376

GO:0003323

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006950

GO:0007049

GO:0007050

GO:0007155

GO:0007165

GO:0007219

GO:0007568

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0009615

GO:0010468

GO:0010628

GO:0014002

GO:0016301

GO:0016310

GO:0016740

GO:0021542

GO:0021670

GO:0030097

GO:0030154

GO:0030332

GO:0032991

GO:0033077

GO:0034641

GO:0040011

GO:0042063

GO:0042127

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0043697

GO:0045596

GO:0045638

GO:0045646

GO:0045656

GO:0045668

GO:0045786

GO:0048146

GO:0048699

GO:0048856

GO:0048870

GO:0050680

GO:0051301

GO:0060218

GO:0097132

GO:0098770

GO:1902036

GO:2000134

GO:2000145

GO:2000773

HGNC:1777

HPA002637

Hs.143857.0.A1_3p_at

Hs.180059.0.S1_3p_at

Hs.180059.0.S2_3p_at

Hs.180059.0.S3_3p_at

Hs.209382.0.A1_3p_at

Hs.253015.0.A1_3p_at

ILMN_1802615

IPR000719

IPR008271

IPR011009

IPR017441

IPR028788

LRG_991

LRG_991t1

MIM:603368

MIM:616080

NM_001145306

NM_001259

NP_001138778

NP_001250

PF00069

PH_hs_0002992

SM00220

TC07001603.hg

TC07003061.hg

UPI00001108FA

X66365

X66365_at

XM_006715835

XP_006715898

Participant Of

hasCandidate

p-T172-CDK4,p-T177-CDK6 [nucleoplasm]

Other forms of this molecule

CDK6 [cytosol]

CDK6 [nucleoplasm]

Inferred To

phospho-p-T177-CDK6 [nucleoplasm] (Bos taurus)

phospho-p-T177-CDK6 [nucleoplasm] (Danio rerio)

phospho-p-T177-CDK6 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T177-CDK6 [nucleoplasm] (Mus musculus)

phospho-p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)

phospho-p-T177-CDK6 [nucleoplasm] (Sus scrofa)

phospho-p-T177-CDK6 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 177

Coordinate

177

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001138778.1, XP_006715898.1, NP_001250.1

ZINC - World Drugs

CDK6_HUMAN

OpenTargets

ENSG00000105810

ZINC - FDA approved

CDK6_HUMAN

ZINC - Substances

CDK6_HUMAN

ZINC target

Q00534

ZINC - Biogenic

CDK6_HUMAN

PRO

Q00534

PDB

5L2S, 5L2T, 2F2C, 1BI8, 2EUF, 1JOW, 4EZ5, 1BLX, 3NUP, 1G3N, 1BI7, 5L2I, 3NUX, 1XO2, 4AUA, 4TTH

ZINC - Investigational

CDK6_HUMAN

ZINC - Metabolites

CDK6_HUMAN

GeneCards

Q00534

Orphanet

22579

ZINC - Predictions - Purchasable

CDK6_HUMAN

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.961	21
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.959	18
UniProt:P42771 CDKN2A	80	p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294) p16INK4A E10* [cytosol] (R-HSA-9648382) p16INK4A S12* [cytosol] (R-HSA-9648383) p16INK4A P114T [cytosol] (R-HSA-9631034) p16INK4A P114S [cytosol] (R-HSA-9631027) p16INK4A G23fs3 [cytosol] (R-HSA-9648652) p16INK4A E61 [cytosol] (R-HSA-9648396) p16INK4A A20T [cytosol] (R-HSA-9630861) p16INK4A A36fs17 [cytosol] (R-HSA-9648653) p16INK4A E69 [cytosol] (R-HSA-9648397) p16INK4A W15fs1 [cytosol] (R-HSA-9648654) p16INK4A Y44 [cytosol] (R-HSA-9648398) p16INK4A T18fs15 [cytosol] (R-HSA-9648655) p16INK4A E26 [cytosol] (R-HSA-9648392) p16INK4A E33* [cytosol] (R-HSA-9648393) p16INK4A Q50* [cytosol] (R-HSA-9648394) p16INK4A E120* [cytosol] (R-HSA-9632587) p16INK4A S7fs8 [cytosol] (R-HSA-9648651) p16INK4A W15 [cytosol] (R-HSA-9648395) p16INK4A P75* [cytosol] (R-HSA-9648388) p16INK4A C72* [cytosol] (R-HSA-9648389) p16INK4A E119* [cytosol] (R-HSA-9648390) p16INK4A A20E [cytosol] (R-HSA-9630855) p16INK4A N39fs14 [cytosol] (R-HSA-9648647) p16INK4A P114R [cytosol] (R-HSA-9631046) p16INK4A P114H [cytosol] (R-HSA-9631043) p16INK4A E27 [cytosol] (R-HSA-9648387) p16INK4A P81S [cytosol] (R-HSA-9632287) p16INK4A G101V [cytosol] (R-HSA-9631263) p16INK4A Y44fs1 [cytosol] (R-HSA-9648664) p16INK4A V126I [cytosol] (R-HSA-9631130) p16INK4A L16fs9 [cytosol] (R-HSA-9648663) p16INK4A V126A [cytosol] (R-HSA-9631126) p16INK4A T18fs8 [cytosol] (R-HSA-9648656) p16INK4A V126F [cytosol] (R-HSA-9631120) p16INK4A L37fs16 [cytosol] (R-HSA-9648659) p16INK4A G35V [cytosol] (R-HSA-9631308) p16INK4A G23D [cytosol] (R-HSA-9630892) p16INK4A R24P [cytosol] (R-HSA-9630828) p16INK4A R80P [cytosol] (R-HSA-9632270) p16INK4A G35A [cytosol] (R-HSA-9631306) p16INK4A E88K [cytosol] (R-HSA-9632548) p16INK4A T77P [cytosol] (R-HSA-9632257) p16INK4A L97R [cytosol] (R-HSA-9632512) p16INK4A T18_A19dup [cytosol] (R-HSA-9632192) p16INK4A G67_N71del [cytosol] (R-HSA-9632252) p16INK4A A60R [cytosol] (R-HSA-9632216) p16INK4A D74Y [cytosol] (R-HSA-9632088) p16INK4A A60V [cytosol] (R-HSA-9632212) p16INK4A R112_L113insR [cytosol] (R-HSA-9632566) p16INK4A R99P [cytosol] (R-HSA-9632531) p16INK4A [cytosol] (R-HSA-182578) p16INK4A G35E [cytosol] (R-HSA-9631314) p16INK4A G35W [cytosol] (R-HSA-9631328) p16INK4A T77S [cytosol] (R-HSA-9632256) p16INK4A G35R [cytosol] (R-HSA-9631316) p16INK4A G23V [cytosol] (R-HSA-9631157) p16INK4A A60E [cytosol] (R-HSA-9632202) p16INK4A G23S [cytosol] (R-HSA-9631163) p16INK4A L97P [cytosol] (R-HSA-9632523) p16INK4A A60S [cytosol] (R-HSA-9632206)	0.934	15
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.915	15
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.845	11
UniProt:P24385 CCND1	4	p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832)	0.734	4
UniProt:Q01196 RUNX1	5	p-S249,S273,T276-RUNX1 [nucleoplasm] (R-HSA-8878063) RUNX1 [nucleoplasm] (R-HSA-8865295) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) RUNX1 [plasma membrane] (R-HSA-5667138)	0.656	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.646	3
UniProt:P38936 CDKN1A	5	CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.59	2
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463)	0.524	2
UniProt:Q14094 CCNI			0.488	2
UniProt:P41238 APOBEC1	1	APOBEC1(1-236) [nucleoplasm] (R-HSA-49459)	0.488	2
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.488	4
UniProt:Q96D03 DDT4L			0.488	2
UniProt:Q9C019 TRI15			0.488	2
UniProt:Q5XKR4 OTP			0.488	2