Reactome | p-T177-CDK6 [nucleoplasm]

p-T177-CDK6 [nucleoplasm]

Stable Identifier

R-HSA-69628

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Cdk6, Cell division protein kinase 6 , Serine/threonine protein kinase PLSTIRE

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND3 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00534 CDK6

Gene Names

CDK6, CDKN6

Chain

chain:1-326

Reference Genes

BioGPS Gene:1021 CDK6

COSMIC (genes):CDK6 CDK6

CTD Gene:1021 CDK6

dbSNP Gene:1021 CDK6

ENSEMBL:ENSG00000105810.10 CDK6

HGNC:1777 CDK6

KEGG Gene (Homo sapiens):1021 CDK6

Monarch:1021 CDK6

NCBI Gene:1021 CDK6

OMIM:603368 CDK6

UCSC:Q00534 CDK6

Reference Transcript

Other Identifiers

0002510520

0103850332

1021

11723241_at

11723242_at

11723243_at

11723244_at

1207_at

17059756

207143_PM_at

207143_at

224847_PM_at

224847_at

224848_PM_at

224848_at

224851_PM_at

224851_at

231198_PM_at

231198_at

235287_PM_at

235287_at

243000_PM_at

243000_at

3061320

3061321

3061322

3061323

3061324

3061325

3061326

3061327

3061328

3061329

3061330

3061331

3061336

3061348

3061349

3061360

3061361

3061362

3061385

3061398

3061399

3061400

3061402

3061406

3061407

41545_at

57070_at

65733_at

69864_at

75209_r_at

75491_at

8140955

83673_at

89442_at

91819_at

A_23_P168651

A_24_P166663

GE80452

GE88785

GO:0000082

GO:0000122

GO:0000166

GO:0000278

GO:0000307

GO:0001726

GO:0001954

GO:0002244

GO:0002376

GO:0003323

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006351

GO:0006355

GO:0006468

GO:0007049

GO:0007155

GO:0007219

GO:0007568

GO:0008150

GO:0008285

GO:0008353

GO:0009615

GO:0010468

GO:0010628

GO:0014002

GO:0016301

GO:0016310

GO:0016592

GO:0016740

GO:0021542

GO:0021670

GO:0023052

GO:0030097

GO:0030154

GO:0030332

GO:0032991

GO:0033077

GO:0036211

GO:0042063

GO:0042127

GO:0042995

GO:0043167

GO:0043226

GO:0043697

GO:0045596

GO:0045638

GO:0045646

GO:0045656

GO:0045668

GO:0045786

GO:0048146

GO:0048699

GO:0048856

GO:0048870

GO:0050680

GO:0051301

GO:0051726

GO:0060218

GO:0097132

GO:0098770

GO:0106310

GO:1902036

GO:2000145

GO:2000773

HMNXSV003010950

Hs.143857.0.A1_3p_at

Hs.180059.0.S1_3p_at

Hs.180059.0.S2_3p_at

Hs.180059.0.S3_3p_at

Hs.209382.0.A1_3p_at

Hs.253015.0.A1_3p_at

ILMN_1802615

PH_hs_0002992

TC07001603.hg

TC07003061.hg

X66365_at

g4502740_3p_at

Participates

as a component of

as a candidate of

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CDK6 [cytosol]

CDK6 [nucleoplasm]

Inferred To

phospho-p-T177-CDK6 [nucleoplasm] (Bos taurus)

phospho-p-T177-CDK6 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T177-CDK6 [nucleoplasm] (Canis familiaris)

phospho-p-T177-CDK6 [nucleoplasm] (Danio rerio)

phospho-p-T177-CDK6 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T177-CDK6 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T177-CDK6 [nucleoplasm] (Gallus gallus)

phospho-p-T177-CDK6 [nucleoplasm] (Mus musculus)

phospho-p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)

phospho-p-T177-CDK6 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-T177-CDK6 [nucleoplasm] (Sus scrofa)

phospho-p-T177-CDK6 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 177

Coordinate

177

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_006715898.1, NP_001250.1, NP_001138778.1

ZINC - World Drugs

CDK6_HUMAN

Guide to Pharmacology - Targets

1978

OpenTargets

ENSG00000105810

ZINC - FDA approved

CDK6_HUMAN

ZINC - Substances

CDK6_HUMAN

ZINC target

Q00534

ZINC - Biogenic

CDK6_HUMAN

PRO

Q00534

PDB

6OQL, 5L2T, 6OQO, 3NUP, 1JOW, 5L2S, 1BLX, 5L2I, 2EUF, 4TTH, 1XO2, 1G3N, 1BI8, 4EZ5, 3NUX, 4AUA, 1BI7, 2F2C

ZINC - Investigational

CDK6_HUMAN

ZINC - Metabolites

CDK6_HUMAN

GeneCards

Q00534

HPA

ENSG00000105810-CDK6

Ensembl

ENSG00000105810, ENSP00000397087, ENST00000265734, ENST00000424848, ENSP00000265734

Pharos - Targets

Q00534

ZINC - Predictions - Purchasable

CDK6_HUMAN

Orphanet

22579

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.972	30
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.969	26
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.954	22
UniProt:P42771 CDKN2A	20	p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294)	0.94	16
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.889	16
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.734	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.646	3
UniProt:Q01196 RUNX1	5	RUNX1 [plasma membrane] (R-HSA-5667138) p-S249,S273,T276-RUNX1 [nucleoplasm] (R-HSA-8878063) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) RUNX1 [nucleoplasm] (R-HSA-8865295)	0.628	5
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.615	4
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.59	2
UniProt:Q14094 CCNI			0.556	3
UniProt:P41238 APOBEC1	1	APOBEC1(1-236) [nucleoplasm] (R-HSA-49459)	0.556	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.556	5
UniProt:Q9C019 TRI15			0.556	3
UniProt:Q5XKR4 OTP			0.556	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2

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