Reactome | p-T177-CDK6 [nucleoplasm]

p-T177-CDK6 [nucleoplasm]

Stable Identifier

R-HSA-69628

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Cdk6, Cell division protein kinase 6 , Serine/threonine protein kinase PLSTIRE

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6:CCND3 [nucleoplasm] (Homo sapiens)
        
        p-T177-CDK6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00534 CDK6

Gene Names

CDK6, CDKN6

Chain

chain:1-326

Reference Genes

BioGPS Gene:1021 CDK6

COSMIC (genes):CDK6 CDK6

CTD Gene:1021 CDK6

dbSNP Gene:1021 CDK6

ENSEMBL:ENSG00000105810 CDK6

HGNC:1777 CDK6

KEGG:hsa:1021 CDK6

Monarch:1021 CDK6

NCBI Gene:1021 CDK6

OMIM:603368 CDK6

UCSC:Q00534 CDK6

Reference Transcript

Other Identifiers

1021

11723241_at

11723242_at

11723243_at

11723244_at

1207_at

17059756

207143_PM_at

207143_at

224847_PM_at

224847_at

224848_PM_at

224848_at

224851_PM_at

224851_at

231198_PM_at

231198_at

235287_PM_at

235287_at

243000_PM_at

243000_at

3061320

3061321

3061322

3061323

3061324

3061325

3061326

3061327

3061328

3061329

3061330

3061331

3061332

3061336

3061347

3061348

3061349

3061360

3061361

3061362

3061385

3061396

3061397

3061398

3061399

3061400

3061402

3061404

3061406

3061407

41545_at

57070_at

65733_at

69864_at

75209_r_at

75491_at

8140955

83673_at

89442_at

91819_at

A_23_P168651

A_24_P166663

GE80452

GE88785

GO:0000082

GO:0000122

GO:0000307

GO:0001726

GO:0001954

GO:0002244

GO:0002376

GO:0003323

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006355

GO:0006468

GO:0007165

GO:0007219

GO:0008285

GO:0009615

GO:0010389

GO:0010468

GO:0010628

GO:0014002

GO:0016301

GO:0016740

GO:0021542

GO:0021670

GO:0030097

GO:0030154

GO:0030332

GO:0033077

GO:0042063

GO:0042127

GO:0042995

GO:0043226

GO:0043697

GO:0045596

GO:0045638

GO:0045646

GO:0045656

GO:0045668

GO:0045786

GO:0048146

GO:0048699

GO:0048856

GO:0050680

GO:0051301

GO:0051726

GO:0060218

GO:0097131

GO:0097132

GO:0097133

GO:0098770

GO:0106310

GO:0140096

GO:1902036

GO:2000145

GO:2000773

HMNXSV003010950

Hs.143857.0.A1_3p_at

Hs.180059.0.S1_3p_at

Hs.180059.0.S2_3p_at

Hs.180059.0.S3_3p_at

Hs.209382.0.A1_3p_at

Hs.253015.0.A1_3p_at

ILMN_1802615

PH_hs_0002992

TC07001603.hg

TC07003061.hg

X66365_at

g4502740_3p_at

Participates

as a component of

as a candidate of

p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CDK6 [nucleoplasm]

CDK6 [cytosol]

Inferred To

phospho-CDK6 [nucleoplasm] (Bos taurus)

phospho-CDK6 [nucleoplasm] (Canis familiaris)

phospho-CDK6 [nucleoplasm] (Sus scrofa)

Homologues of p-T177-CDK6 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-cdk6 [nucleoplasm] (Gallus gallus)

phospho-cdk6 [nucleoplasm] (Xenopus tropicalis)

phospho-csk1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-Cdk6 [nucleoplasm] (Mus musculus)

phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)

phospho-Cdk4 [nucleoplasm] (Drosophila melanogaster)

phospho-cdc2 [nucleoplasm] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-threonine at 177

Coordinate

177

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001138778.1, NP_001250.1, XP_006715898.1, XP_047275672.1

ZINC - World Drugs

CDK6_HUMAN

Guide to Pharmacology - Targets

1978

OpenTargets

ENSG00000105810

ENSEMBL

ENST00000424848, ENST00000265734, ENSG00000105810, ENSP00000265734, ENSP00000397087

ZINC - FDA approved

CDK6_HUMAN

ZINC - Substances

CDK6_HUMAN

ZINC - Biogenic

CDK6_HUMAN

ZINC target

Q00534

PRO

Q00534

PDB

1BLX, 3NUX, 1G3N, 2EUF, 2F2C, 1BI8, 1JOW, 4EZ5, 3NUP, 5L2I, 1XO2, 6OQO, 5L2S, 6OQL, 4AUA, 5L2T, 4TTH, 1BI7, 8I0M

ZINC - Investigational

CDK6_HUMAN

ZINC - Metabolites

CDK6_HUMAN

HPA

ENSG00000105810-CDK6

GeneCards

CDK6

Pharos - Targets

Q00534

Orphanet

CDK6

ZINC - Predictions - Purchasable

CDK6_HUMAN

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.974	34
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.971	29
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.96	27
UniProt:P42771 CDKN2A	20	p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294)	0.949	19
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.919	19
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.878	8
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.728	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.723	4
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.706	7
UniProt:P38936 CDKN1A	5	CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.688	4
UniProt:Q01196 RUNX1	5	RUNX1 [nucleoplasm] (R-HSA-8865295) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) p-S249,T273,S276-RUNX1 [nucleoplasm] (R-HSA-8878063) RUNX1 [plasma membrane] (R-HSA-5667138)	0.628	5
UniProt:Q8N5C1 CAHM5			0.589	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.571	2
UniProt:Q5XKR4 OTP			0.556	3
UniProt:P41238 APOBEC1	1	APOBEC1(1-236) [nucleoplasm] (R-HSA-49459)	0.556	3
UniProt:Q9C019 TRI15			0.556	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.556	5
UniProt:Q14094 CCNI			0.556	3
UniProt:O60563 CCNT1	1	CCNT1 [nucleoplasm] (R-HSA-51611)	0.527	4
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:Q58FG0 HS905			0.527	3
UniProt:P30279 CCND2	2	CCND2 [cytosol] (R-HSA-68340) CCND2 [nucleoplasm] (R-HSA-113827)	0.527	2
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.471	3
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.471	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.471	2