p-S15,S20-TP53 [nucleoplasm]

Stable Identifier
R-HSA-69683
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
p-S15,S20-TP53 [nucleoplasm] icon
p-S15,S20-TP53 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P04637 TP53
Gene Names
TP53, P53
Chain
chain:1-393
Reference Genes
BioGPS Gene:7157 TP53
COSMIC (genes):TP53 TP53
CTD Gene:7157 TP53
dbSNP Gene:7157 TP53
ENSEMBL:ENSG00000141510 TP53
HGNC:11998 TP53
KEGG Gene (Homo sapiens):7157 TP53
Monarch:7157 TP53
NCBI Gene:7157 TP53
OMIM:191170 TP53
UCSC:P04637 TP53
Reference Transcript
Other Identifiers
0005670112
11738335_x_at
11748319_x_at
11748599_a_at
11750514_x_at
11751536_a_at
11751537_x_at
16840732
1939_at
1974_s_at
1A1U
1AIE
1C26
1DT7
1GZH
1H26
1HS5
1JSP
1KZY
1MA3
1OLG
1OLH
1PES
1PET
1SAE
1SAF
1SAK
1SAL
1TSR
1TUP
1UOL
1XQH
1YC5
1YCQ
1YCR
1YCS
201746_at
211300_s_at
2973
2AC0
2ADY
2AHI
2ATA
2B3G
2BIM
2BIN
2BIO
2BIP
2BIQ
2F1X
2FEJ
2FOJ
2FOO
2GS0
2H1L
2H2D
2H2F
2H4F
2H4H
2H4J
2H59
2J0Z
2J10
2J11
2J1W
2J1X
2J1Y
2J1Z
2J20
2J21
2K8F
2L14
2LY4
2MEJ
2MWO
2MWP
2MWY
2MZD
2OCJ
2PCX
2RUK
2VUK
2WGX
2X0U
2X0V
2X0W
2XWR
2YBG
2YDR
2Z5S
2Z5T
31618_at
3743907
3743908
3743909
3743912
3743913
3743915
3743917
3743918
3743919
3743920
3743922
3743923
3743924
3743925
3743926
3743933
39238
39239
3D05
3D06
3D07
3D08
3D09
3D0A
3DAB
3DAC
3IGK
3IGL
3KMD
3KZ8
3LW1
3OQ5
3PDH
3Q01
3Q05
3Q06
3SAK
3TG5
3TS8
3ZME
4AGL
4AGM
4AGN
4AGP
4AGQ
4BUZ
4BV2
4HFZ
4HJE
4IBQ
4IBS
4IBT
4IBU
4IBV
4IBW
4IBY
4IBZ
4IJT
4KVP
4LO9
4LOE
4LOF
4MZI
4MZR
4QO1
4RP6
4RP7
4X34
4XR8
4ZZJ
51244
5A7B
5AB9
5ABA
5AOI
5AOJ
5AOK
5AOL
5AOM
5BUA
5ECG
5G4M
5G4N
5G4O
5HOU
5HP0
5HPD
5LAP
5LGY
5MCT
5MCU
5MCV
5MCW
5MF7
5MG7
5MHC
5MOC
5O1A
5O1B
5O1C
5O1D
5O1E
5O1F
5O1G
5O1H
5O1I
5OL0
5UN8
6FF9
6FJ5
7157
72876
8012257
A0A087WT22
A0A087WXZ1
A0A087WZU8
A0A087X1Q1
A0A0U1RQC9
A_23_P26810
A_33_P3315764
AAA59987
AAA59988
AAA59989
AAA61211
AAA61212
AAB39322
AAC12971
AAD28535
AAD28628
AAF36354
AAF36355
AAF36356
AAF36357
AAF36358
AAF36359
AAF36360
AAF36361
AAF36362
AAF36374
AAF36375
AAF36376
AAF36377
AAF36378
AAF36379
AAF36380
AAF36381
AAF36382
AAF63442
AAF63443
AAG28785
AAH03596
AAK76358
AAK76359
AAP30003
AAQ90158
AAR10356
AAR13239
AAV80424
AB082923
ABA29753
ABA29754
ABA29755
ABA29756
ABA29757
ABB80262
ABB80266
AC007421
AC087388
AEX20383
AF135120
AF135121
AF136270
AF136271
AF209128
AF209129
AF209130
AF209131
AF209132
AF209133
AF209134
AF209135
AF209136
AF209148
AF209149
AF209150
AF209151
AF209152
AF209153
AF209154
AF209155
AF209156
AF210308
AF210309
AF210310
AF240684
AF240685
AF307851
AFN61604
AFN61605
AK312568
AY270155
AY359814
AY390341
AY429684
AY838896
AYE20619
BAC16799
BAG35463
BC003596
CAA25652
CAA26306
CAA38095
CAA42626
CAA42627
CAA42628
CAA42629
CAA42630
CAA42631
CAA42632
CAA42633
CAA42634
CAA42635
CAB002973
CAB039238
CAB039239
CAB072876
CCDS11118
CCDS45605
CCDS45606
CCDS73966
CCDS73967
CCDS73968
CCDS73969
CCDS73970
CCDS73971
CH471108
DQ186648
DQ186649
DQ186650
DQ186651
DQ186652
DQ191317
DQ286964
E7EMR6
E7EQX7
E7ESS1
E9PCY9
E9PFT5
EAW90143
EAW90144
ENSG00000141510
ENSP00000269305
ENSP00000391127
ENSP00000391478
ENSP00000398846
ENSP00000478219
ENSP00000478499
ENSP00000480868
ENSP00000481179
ENSP00000481638
ENSP00000482222
ENSP00000482258
ENSP00000482537
ENSP00000484409
ENST00000269305
ENST00000269305.8
ENST00000420246
ENST00000420246.6
ENST00000445888
ENST00000445888.6
ENST00000455263
ENST00000455263.6
ENST00000504290
ENST00000504290.5
ENST00000504937
ENST00000504937.5
ENST00000510385
ENST00000510385.5
ENST00000610292
ENST00000610292.4
ENST00000610538
ENST00000610538.4
ENST00000617185
ENST00000617185.4
ENST00000619485
ENST00000619485.4
ENST00000620739
ENST00000620739.4
ENST00000622645
ENST00000622645.4
EntrezGene:7157
EntrezGene:TP53
g189478_3p_a_at
g8400737_3p_at
g8400737_3p_x_at
GE58227
GO:0000122
GO:0000228
GO:0000278
GO:0000733
GO:0000790
GO:0000977
GO:0000978
GO:0000980
GO:0000981
GO:0001046
GO:0001085
GO:0001094
GO:0001228
GO:0001701
GO:0001756
GO:0001836
GO:0002020
GO:0002039
GO:0002244
GO:0002309
GO:0002326
GO:0002360
GO:0002376
GO:0002931
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0003729
GO:0003730
GO:0005507
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005657
GO:0005667
GO:0005669
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005783
GO:0005829
GO:0005975
GO:0006091
GO:0006259
GO:0006284
GO:0006289
GO:0006302
GO:0006355
GO:0006357
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006914
GO:0006915
GO:0006950
GO:0006974
GO:0006977
GO:0006978
GO:0006979
GO:0006983
GO:0007005
GO:0007049
GO:0007050
GO:0007165
GO:0007179
GO:0007265
GO:0007275
GO:0007369
GO:0007406
GO:0007417
GO:0007507
GO:0007568
GO:0007569
GO:0007623
GO:0008104
GO:0008134
GO:0008150
GO:0008156
GO:0008219
GO:0008270
GO:0008283
GO:0008285
GO:0008340
GO:0009056
GO:0009058
GO:0009299
GO:0009303
GO:0009411
GO:0009651
GO:0009790
GO:0009792
GO:0010165
GO:0010332
GO:0010628
GO:0010629
GO:0010666
GO:0012501
GO:0016032
GO:0016363
GO:0016579
GO:0016604
GO:0016605
GO:0019221
GO:0019899
GO:0019901
GO:0019903
GO:0021549
GO:0022607
GO:0030154
GO:0030234
GO:0030308
GO:0030330
GO:0030512
GO:0030971
GO:0031065
GO:0031497
GO:0031571
GO:0031625
GO:0032461
GO:0032991
GO:0033077
GO:0034103
GO:0034641
GO:0034644
GO:0035033
GO:0035035
GO:0035264
GO:0035690
GO:0035794
GO:0035861
GO:0036003
GO:0040007
GO:0042127
GO:0042149
GO:0042493
GO:0042771
GO:0042802
GO:0042803
GO:0042826
GO:0042981
GO:0043065
GO:0043066
GO:0043153
GO:0043167
GO:0043226
GO:0043504
GO:0043516
GO:0043523
GO:0043525
GO:0043621
GO:0044212
GO:0044281
GO:0044403
GO:0045861
GO:0045892
GO:0045893
GO:0045899
GO:0045930
GO:0045944
GO:0046677
GO:0046827
GO:0046872
GO:0046902
GO:0046982
GO:0047485
GO:0048147
GO:0048511
GO:0048512
GO:0048539
GO:0048568
GO:0048646
GO:0048856
GO:0050731
GO:0050821
GO:0051087
GO:0051097
GO:0051123
GO:0051262
GO:0051276
GO:0051289
GO:0051402
GO:0051721
GO:0051726
GO:0051974
GO:0060218
GO:0060333
GO:0060411
GO:0061024
GO:0061419
GO:0062100
GO:0065003
GO:0070059
GO:0070243
GO:0070245
GO:0070266
GO:0071158
GO:0071456
GO:0071479
GO:0071480
GO:0071494
GO:0071850
GO:0072331
GO:0072332
GO:0072363
GO:0072717
GO:0090200
GO:0090343
GO:0090399
GO:0090403
GO:0097193
GO:0097252
GO:0097371
GO:0097718
GO:1900119
GO:1900740
GO:1901525
GO:1901796
GO:1902108
GO:1902253
GO:1902749
GO:1902895
GO:1903799
GO:1903800
GO:1904024
GO:1990144
GO:1990440
GO:1990841
GO:2000269
GO:2000378
GO:2000379
GO:2000772
GO:2001244
H2EHT1
HGNC:11998
HPA051244
ILMN_1779356
IPR002117
IPR008967
IPR010991
IPR011615
IPR012346
IPR013872
IPR036674
IPR040926
J3KP33
JN900492
JQ694049
JQ694050
K03199
K7PPA8
LRG_321
LRG_321t1
LRG_321t2
LRG_321t3
LRG_321t4
LRG_321t6
LRG_321t8
M13112
M13113
M13114
M13115
M13116
M13117
M13118
M13119
M13120
M13121
M14694
M14695
M22882
M22883
M22884
M22887
M22888
M22894
M22895
M22896
M22897
M22898
M22898_at
MG595988
MIM:114480
MIM:114500
MIM:114550
MIM:137800
MIM:151623
MIM:191170
MIM:202300
MIM:259500
MIM:260350
MIM:260500
MIM:607107
MIM:614740
MIM:618165
NM_000546
NM_001126112
NM_001126113
NM_001126114
NM_001126116
NM_001126118
NM_001276695
NM_001276696
NM_001276698
NM_001276760
NM_001276761
NP_000537
NP_001119584
NP_001119585
NP_001119586
NP_001119588
NP_001119590
NP_001263624
NP_001263625
NP_001263627
NP_001263689
NP_001263690
PF00870
PF07710
PF08563
PF18521
PH_hs_0019846
PR00386
S4R334
TC17001094.hg
TC17002468.hg
TP53
TP53-201
TP53-204
TP53-205
TP53-206
TP53-208
TP53-209
TP53-213
TP53-219
TP53-220
TP53-223
TP53-226
TP53-227
TP53-228
U63714
U94788
UPI000002ED67
UPI000040A8D3
UPI000041E410
UPI0000456A12
UPI00005B7310
UPI00005B7311
UPI00005B7312
UPI0001FDB80B
UPI0001FDB80C
X01405
X02469
X54156
X60011
X60012
X60013
X60014
X60015
X60016
X60017
X60018
X60019
X60020
Participant Of
hasComponent
Other forms of this molecule
Unfolded TP53 [cytosol]
TP53 [cytosol]
PolyUb-TP53 [nucleoplasm]
SUMO2,3-K386-TP53 [nucleoplasm]
Me2K-370,382-TP53 [nucleoplasm]
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
Me2-K373-TP53 [nucleoplasm]
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
MeK-370,p-S15,S20-TP53 [nucleoplasm]
Me-K382,p-S15,S20-TP53 [nucleoplasm]
PolyUb,p-S15,S20-TP53 [nucleoplasm]
p-S15,S392-TP53 [nucleoplasm]
p-S315-TP53 [nucleoplasm]
p-S15,S20,S269,T284-TP53 [nucleoplasm]
p-S15,S33,S46-TP53 [nucleoplasm]
p-S15,S20,S392-TP53 [nucleoplasm]
p-T55-TP53 [nucleoplasm]
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
p-S37-TP53 [nucleoplasm]
p-S15,S20,S46-TP53 [nucleoplasm]
PolyUb-TP53 [nucleoplasm]
PolyUb-TP53 [cytosol]
p-S15-TP53 [nucleoplasm]
TP53 [nucleoplasm]
Inferred To
Ghost homologue of p-S15,S20-TP53 [nucleoplasm] (Canis familiaris)
Ghost homologue of p-S15,S20-TP53 [nucleoplasm] (Gallus gallus)
phospho-p-S15,S20-TP53 [nucleoplasm] (Bos taurus)
phospho-p-S15,S20-TP53 [nucleoplasm] (Danio rerio)
phospho-p-S15,S20-TP53 [nucleoplasm] (Drosophila melanogaster)
phospho-p-S15,S20-TP53 [nucleoplasm] (Mus musculus)
phospho-p-S15,S20-TP53 [nucleoplasm] (Rattus norvegicus)
phospho-p-S15,S20-TP53 [nucleoplasm] (Sus scrofa)
phospho-p-S15,S20-TP53 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 20
Coordinate
20
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 15
Coordinate
15
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
GeneCards
ZINC - Substances
ZINC target
PRO
Orphanet
ZINC - Predictions - Purchasable
PDB
2MWO, 5HOU, 5O1E, 1C26, 2AC0, 5HP0, 3DAB, 4XR8, 2J1W, 2H59, 2AHI, 1PET, 2ATA, 4AGL, 2MEJ, 3LW1, 1SAK, 2MWP, 3DAC, 5MCV, 5XZC, 5O1D, 6GGE, 2LY4, 1HS5, 1H26, 5LAP, 2GS0, 4IBV, 4RP6, 5MHC, 2X0U, 2WGX, 3KMD, 2J11, 1YCS, 2BIP, 2MWY, 3D08, 4LOE, 5OL0, 1KZY, 2H4J, 3TS8, 3TG5, 6GGD, 2XWR, 2H1L, 4IJT, 2YDR, 2K8F, 5ABA, 6GGB, 3D05, 5AOM, 1SAF, 2FOO, 1YCR, 5AB9, 2J10, 5MG7, 3Q05, 2J0Z, 5LGY, 1JSP, 1YCQ, 2BIN, 1AIE, 5MCU, 3Q06, 3D06, 2PCX, 4LO9, 5O1I, 3IGL, 1SAL, 5G4M, 2YBG, 4MZR, 4HJE, 2J1Z, 4IBZ, 3IGK, 5O1A, 1A1U, 4IBT, 4AGM, 3KZ8, 4ZZJ, 2MZD, 5O1H, 4IBU, 1SAE, 1PES, 2L14, 1GZH, 2VUK, 4IBQ, 5O1F, 4KVP, 4IBS, 4RP7, 2H2D, 5O1C, 2ADY, 4LOF, 4BV2, 2J20, 4AGQ, 5G4O, 1TUP, 2B3G, 4BUZ, 2F1X, 2J1X, 5MCT, 5AOI, 2X0V, 4IBY, 2BIQ, 6GGF, 5A7B, 5ECG, 3D09, 3SAK, 5AOJ, 2J1Y, 4AGP, 2H4F, 5G4N, 6GGC, 2RUK, 2OCJ, 2FEJ, 1DT7, 6FJ5, 3D0A, 6FF9, 3PDH, 2H4H, 6GGA, 2BIM, 5MOC, 1OLG, 5BUA, 5MF7, 5AOL, 1MA3, 2BIO, 3ZME, 1OLH, 5O1B, 5MCW, 4QO1, 3D07, 4HFZ, 4X34, 1TSR, 5AOK, 1UOL, 3OQ5, 4IBW, 2Z5S, 1XQH, 1YC5, 5HPD, 4AGO, 2H2F, 2J21, 3Q01, 5UN8, 5O1G, 2X0W, 4MZI, 2Z5T, 4AGN, 2FOJ
Interactors (191)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q00987 MDM2  11 0.994 98
 UniProt:P04637 TP53  27 0.978 25
 UniProt:Q09472 EP300  5 0.974 21
 IntAct:EBI-4399559 UBIQ      0.973 21
 UniProt:P03070 LT      0.969 23
 UniProt:Q93009 USP7  2 0.968 22
 UniProt:O15151 MDM4  5 0.964 19
 UniProt:P0CG48 UBC  316 0.96 15
 UniProt:Q96EB6 SIRT1  1 0.957 18
 IntAct:EBI-1550784 CDKN1A      0.929 22
 UniProt:Q8WTS6 SETD7  1 0.922 11
 UniProt:Q92793 CREBBP  3 0.911 11
 UniProt:Q07817-1 BCL2L1      0.881 26
 UniProt:Q12888-1 TP53BP1      0.879 17
 UniProt:Q96PM5 RCHY1  2 0.849 11
 UniProt:Q13526 PIN1  2 0.846 14
 UniProt:Q9UER7 DAXX  2 0.845 12
 UniProt:P06463 VE6      0.84 5
 UniProt:Q12888 TP53BP1  3 0.829 6
 UniProt:Q13625 TP53BP2  1 0.829 7
 UniProt:Q15672 TWIST1  1 0.817 10
 UniProt:Q8WUF5 PPP1R13L  1 0.815 12
 UniProt:P38646 HSPA9  6 0.811 6
 UniProt:P03126 VE6      0.807 5
 UniProt:Q9NRG4 SMYD2  1 0.806 6
 UniProt:P45481 Crebbp  4 0.797 9
 UniProt:P26447 S10A4      0.787 7
 UniProt:Q05086 UBE3A  1 0.77 6
 UniProt:Q923E4 Sirt1  2 0.766 4
 UniProt:Q99986 VRK1  2 0.761 11
 UniProt:Q05397 PTK2  11 0.761 13
 UniProt:P09874 PARP1  4 0.75 5
 UniProt:P09429 HMGB1  5 0.74 9
 UniProt:P53350 PLK1