p-S15,S20-TP53 [nucleoplasm]

Stable Identifier
R-HSA-69683
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
p-S15,S20-TP53 [nucleoplasm] icon
p-S15,S20-TP53 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P04637 TP53
Gene Names
TP53, P53
Chain
chain:1-393
Reference Genes
BioGPS Gene:7157 TP53
COSMIC (genes):TP53 TP53
CTD Gene:7157 TP53
dbSNP Gene:7157 TP53
ENSEMBL:ENSG00000141510 TP53
HGNC:11998 TP53
KEGG Gene (Homo sapiens):7157 TP53
Monarch:7157 TP53
NCBI Gene:7157 TP53
OMIM:191170 TP53
UCSC:P04637 TP53
Reference Transcript
Other Identifiers
0005670112
11738335_x_at
11748319_x_at
11748599_a_at
11750514_x_at
11751536_a_at
11751537_x_at
16840732
1939_at
1974_s_at
201746_at
211300_s_at
31618_at
3743907
3743908
3743909
3743912
3743913
3743915
3743917
3743918
3743919
3743920
3743922
3743923
3743924
3743925
3743926
3743933
7157
8012257
A_23_P26810
A_33_P3315764
GE58227
GO:0000122
GO:0000228
GO:0000278
GO:0000733
GO:0000790
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001046
GO:0001085
GO:0001094
GO:0001228
GO:0001701
GO:0001756
GO:0001836
GO:0002020
GO:0002039
GO:0002244
GO:0002309
GO:0002326
GO:0002360
GO:0002376
GO:0002931
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0003729
GO:0003730
GO:0005507
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005654
GO:0005657
GO:0005667
GO:0005669
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005783
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005975
GO:0006091
GO:0006259
GO:0006289
GO:0006302
GO:0006355
GO:0006357
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006914
GO:0006915
GO:0006950
GO:0006974
GO:0006977
GO:0006978
GO:0006979
GO:0006983
GO:0007005
GO:0007049
GO:0007050
GO:0007165
GO:0007179
GO:0007265
GO:0007369
GO:0007406
GO:0007417
GO:0007507
GO:0007568
GO:0007569
GO:0007623
GO:0008104
GO:0008134
GO:0008150
GO:0008156
GO:0008219
GO:0008270
GO:0008283
GO:0008285
GO:0008340
GO:0009056
GO:0009058
GO:0009299
GO:0009303
GO:0009411
GO:0009651
GO:0009790
GO:0009792
GO:0010165
GO:0010332
GO:0010628
GO:0010629
GO:0010666
GO:0012501
GO:0015031
GO:0016032
GO:0016363
GO:0016579
GO:0016604
GO:0016605
GO:0019221
GO:0019748
GO:0019899
GO:0019901
GO:0019903
GO:0021549
GO:0022607
GO:0030154
GO:0030234
GO:0030308
GO:0030330
GO:0030512
GO:0030971
GO:0031065
GO:0031497
GO:0031571
GO:0031625
GO:0031965
GO:0032991
GO:0033077
GO:0033209
GO:0034103
GO:0034641
GO:0034644
GO:0035033
GO:0035035
GO:0035264
GO:0035690
GO:0035794
GO:0035861
GO:0036003
GO:0040007
GO:0042127
GO:0042149
GO:0042493
GO:0042771
GO:0042802
GO:0042826
GO:0042981
GO:0043065
GO:0043066
GO:0043153
GO:0043167
GO:0043226
GO:0043504
GO:0043516
GO:0043523
GO:0043525
GO:0043621
GO:0044212
GO:0044281
GO:0044403
GO:0045861
GO:0045892
GO:0045893
GO:0045899
GO:0045930
GO:0045944
GO:0046677
GO:0046827
GO:0046872
GO:0046982
GO:0047485
GO:0048147
GO:0048511
GO:0048512
GO:0048539
GO:0048568
GO:0048646
GO:0048856
GO:0050731
GO:0050821
GO:0051087
GO:0051097
GO:0051262
GO:0051276
GO:0051402
GO:0051721
GO:0051726
GO:0051974
GO:0060218
GO:0060333
GO:0060411
GO:0061024
GO:0061419
GO:0062100
GO:0065003
GO:0070059
GO:0070243
GO:0070245
GO:0070266
GO:0071158
GO:0071456
GO:0071479
GO:0071480
GO:0071494
GO:0071850
GO:0072331
GO:0072332
GO:0072717
GO:0090200
GO:0090343
GO:0090399
GO:0090403
GO:0097193
GO:0097252
GO:0097371
GO:0097718
GO:1900119
GO:1900740
GO:1901525
GO:1901796
GO:1902108
GO:1902253
GO:1902749
GO:1902895
GO:1903799
GO:1903800
GO:1904024
GO:1905856
GO:1990144
GO:1990248
GO:1990440
GO:1990841
GO:2000269
GO:2000378
GO:2000379
GO:2000772
GO:2001244
ILMN_1779356
M22898_at
PH_hs_0019846
TC17001094.hg
TC17002468.hg
g189478_3p_a_at
g8400737_3p_at
g8400737_3p_x_at
Participant Of
hasComponent
Other forms of this molecule
Unfolded TP53 [cytosol]
TP53 [cytosol]
PolyUb-TP53 [nucleoplasm]
SUMO2,3-K386-TP53 [nucleoplasm]
Me2K-370,382-TP53 [nucleoplasm]
p-S15,S33,S46-TP53 [nucleoplasm]
p-S15,S392-TP53 [nucleoplasm]
p-T55-TP53 [nucleoplasm]
p-S15,S20,S392-TP53 [nucleoplasm]
p-S15,S20,S269,T284-TP53 [nucleoplasm]
p-S315-TP53 [nucleoplasm]
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
Me2-K373-TP53 [nucleoplasm]
MeK-370,p-S15,S20-TP53 [nucleoplasm]
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
Me-K382,p-S15,S20-TP53 [nucleoplasm]
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
p-S15,S20,S46-TP53 [nucleoplasm]
p-S37-TP53 [nucleoplasm]
PolyUb,p-S15,S20-TP53 [nucleoplasm]
PolyUb-TP53 [nucleoplasm]
PolyUb-TP53 [cytosol]
p-S15-TP53 [nucleoplasm]
TP53 [nucleoplasm]
Inferred To
phospho-TP53 [nucleoplasm] (Bos taurus)
phospho-TP53 [nucleoplasm] (Sus scrofa)
phospho-Tp53 [nucleoplasm] (Mus musculus)
phospho-Tp53 [nucleoplasm] (Rattus norvegicus)
Ghost homologue of p-S15,S20-TP53 [nucleoplasm] (Canis familiaris)
Ghost homologue of p-S15,S20-TP53 [nucleoplasm] (Dictyostelium discoideum)
Ghost homologue of p-S15,S20-TP53 [nucleoplasm] (Gallus gallus)
phospho-p53 [nucleoplasm] (Drosophila melanogaster)
phospho-tp53 [nucleoplasm] (Danio rerio)
phospho-p-S15,S20-TP53 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 20
Coordinate
20
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 15
Coordinate
15
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
ZINC - Substances
HPA
GeneCards
Ensembl
ZINC target
PRO
ZINC - Predictions - Purchasable
Orphanet
PDB
4AGN, 6V4H, 3OQ5, 6RZ3, 3KMD, 2H1L, 5AB9, 3D08, 4LOE, 5MCU, 7BWN, 3D07, 5MCV, 4LOF, 5ABA, 2VUK, 2H2D, 4IBY, 1SAK, 2BIO, 4ZZJ, 6RKI, 3Q01, 2H59, 6RKK, 4AGO, 1MA3, 6GGE, 1SAF, 4MZR, 6RJZ, 2FEJ, 2X0U, 6RX2, 4IBS, 5XZC, 4QO1, 4IBQ, 2GS0, 1AIE, 4HFZ, 5O1F, 6S39, 5OL0, 5HPD, 6SI4, 6SL6, 1SAE, 4MZI, 6SI3, 2MZD, 2Z5T, 5MHC, 1A1U, 3D09, 6RM7, 5O1B, 6RL3, 2K8F, 6SI0, 1SAL, 5AOL, 1HS5, 1TSR, 2YBG, 5MCW, 6VRN, 3Q06, 2AHI, 4BUZ, 4AGQ, 4BV2, 6SIO, 3Q05, 4IBZ, 2H2F, 6FF9, 1C26, 4AGP, 6S9Q, 3D0A, 1PES, 1JSP, 6RKM, 2ATA, 5AOJ, 1YC5, 2X0V, 1XQH, 4IBT, 6T58, 6SIN, 2BIP, 2ADY, 1UOL, 2MEJ, 4IBW, 2B3G, 6VR5, 1H26, 5O1G, 4HJE, 2J1X, 5O1H, 5A7B, 5AOI, 2J1W, 5LGY, 2X0W, 4IBU, 5UN8, 2FOJ, 1GZH, 1OLG, 5O1C, 4X34, 5HOU, 2MWP, 1YCR, 5HP0, 6RL4, 5O1D, 5AOM, 2PCX, 1DT7, 6RL6, 5MOC, 4KVP, 2J0Z, 6SIP, 3DAB, 5MF7, 3ZME, 6SLV, 6GGB, 6FJ5, 5G4M, 1PET, 2OCJ, 5LAP, 2RUK, 6SIQ, 2WGX, 2YDR, 6RM5, 2LY4, 5AOK, 6SHZ, 2BIQ, 6GGA, 4XR8, 6RWI, 1YCQ, 2J1Z, 2MWO, 2H4F, 6RWH, 2J1Y, 2F1X, 3SAK, 4IBV, 3PDH, 5O1A, 5O1I, 5G4O, 5MCT, 4AGM, 2H4J, 4RP7, 6V4F, 5MG7, 6GGF, 2MWY, 2H4H, 6VR1, 4AGL, 1YCS, 5BUA, 3LW1, 2J21, 3D06, 6VRM, 5O1E, 2J11, 2BIN, 2AC0, 4IJT, 6GGC, 2FOO, 1OLH, 2J10, 2BIM, 4LO9, 2XWR, 5G4N, 3KZ8, 4RP6, 6GGD, 3IGL, 1KZY, 3TG5, 3TS8, 3IGK, 6RWU, 2Z5S, 3DAC, 6RK8, 1TUP, 2J20, 6SI2, 3D05, 6SI1, 2L14, 5ECG, 6RWS
Interactors (208)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q00987 MDM2  11 0.994 98
 UniProt:P04637 TP53  27 0.979 32
 UniProt:Q09472 EP300  5 0.974 21
 IntAct:EBI-4399559 UBIQ      0.973 21
 UniProt:P03070 LT      0.97 25
 UniProt:Q93009 USP7  2 0.968 22
 UniProt:O15151 MDM4  5 0.964 19
 UniProt:P0CG48 UBC  325 0.96 15
 UniProt:Q96EB6 SIRT1  1 0.957 18
 IntAct:EBI-1550784 CDKN1A      0.929 22
 UniProt:Q8WTS6 SETD7  1 0.922 11
 UniProt:Q92793 CREBBP  3 0.911 11
 UniProt:Q13625 TP53BP2  1 0.903 9
 UniProt:Q96PM5 RCHY1  2 0.892 13
 UniProt:Q07817-1 BCL2L1      0.881 26
 UniProt:Q12888-1 TP53BP1      0.879 17
 UniProt:P26447 S10A4      0.851 9
 UniProt:Q13526 PIN1  2 0.846 14
 UniProt:Q9UER7 DAXX  13 0.845 12
 UniProt:P06463 VE6      0.84 5
 UniProt:Q12888 TP53BP1  3 0.829 6
 UniProt:Q15672 TWIST1  1 0.817 10
 UniProt:Q8WUF5 PPP1R13L  1 0.815 12
 UniProt:P38646 HSPA9  6 0.811 6
 UniProt:P03126 VE6      0.807 5
 UniProt:Q9NRG4 SMYD2  1 0.806 6
 UniProt:P45481 Crebbp  4 0.797 9
 UniProt:O14641 DVL2  5 0.778 6
 UniProt:Q05086 UBE3A  1 0.77 6
 UniProt:Q923E4 Sirt1  2 0.766 4
 UniProt:Q99986 VRK1  2 0.761 11
 UniProt:Q05397 PTK2  11 0.761 13
 UniProt:P09874 PARP1  4 0.75 5
 UniProt:P09429 HMGB1  5 0.74 9
 UniProt:P53350 PLK1  4 0.737 6
 UniProt:P63279 UBE2I  8 0.737 5
 UniProt:Q13547 HDAC1  2 0.734 7
 UniProt:P43356 MAGA2      0.729 7
 UniProt:Q9NPI1 BRD7  1 0.729 9
 UniProt:O14503 BHLHE40  1 0.728 11
 UniProt:Q14999 CUL7  1 0.723 5
 UniProt:P63165 SUMO1  155 0.722 3
 UniProt:P29590 PML  5 0.721 4
 UniProt:P32776  1 0.719 7
 UniProt:P32780 GTF2H1  1 0.719 12
 UniProt:Q8NHY2 COP1  3 0.717 5
 UniProt:Q8IWT3 CUL9  2 0.716 4
 UniProt:Q96KB5 TOPK      0.715 7
 UniProt:P13693 TCTP      0.715 7
 UniProt:Q16666-2 IFI16      0.715 6
 UniProt:Q9H2X6 HIPK2  3 0.713 3
 UniProt:P42858 HTT  1 0.709 19
 UniProt:Q15796 SMAD2  27