Transcriptional activation of cell cycle inhibitor p21

Stable Identifier
R-HSA-69895
Type
Pathway
Species
Homo sapiens
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Both p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).

Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

el-Deiry, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, Trent, JM, Lin, D, Mercer, WE, Kinzler, KW, Vogelstein, B

Cell 1993
Participants
Participant Of
Orthologous Events
Created