Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
DLD [mitochondrial matrix]
Stable Identifier
R-HSA-69978
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Dihydrolipoamide dehydrogenase, mitochondrial, Glycine cleavage system L protein
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
OGDH complex synthesizes succinyl-CoA from 2-OG (Homo sapiens)
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
DLST transfers succinyl to CoA (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
OGDH dimer decarboxylates 2-OG (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
PDH complex synthesizes acetyl-CoA from PYR (Homo sapiens)
DLAT trimer transfers acetyl to CoA (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
aKADH E3 dimer [mitochondrial matrix] (Homo sapiens)
DLD:FAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
aKADH E3 dimer [mitochondrial matrix] (Homo sapiens)
DLD:FAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
PDP1,2 dephosphorylate p-lipo-PDH (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
aKADH E3 dimer [mitochondrial matrix] (Homo sapiens)
DLD:FAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV (Homo sapiens)
BCKDH [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
BCKDK phosphorylates BCKDH (Homo sapiens)
BCKDH [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
p-BCKDH [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
PPM1K dephosphorylates p-BCKDH (Homo sapiens)
BCKDH [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
p-BCKDH [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Glycine degradation (Homo sapiens)
DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Lysine catabolism (Homo sapiens)
alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Homo sapiens)
OADH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
aKADH E3 dimer [mitochondrial matrix] (Homo sapiens)
DLD:FAD [mitochondrial matrix] (Homo sapiens)
DLD [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15946682
Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations
Tomchick, DR
,
Machius, M
,
Chuang, DT
,
Chuang, JL
,
Brautigam, CA
J Mol Biol
2005
External Reference Information
External Reference
UniProt:P09622 DLD
Gene Names
DLD, GCSL, LAD, PHE3
Chain
transit peptide:1-35, chain:36-509
Reference Genes
BioGPS Gene:1738 DLD
COSMIC (genes):DLD DLD
CTD Gene:1738 DLD
dbSNP Gene:1738 DLD
ENSEMBL:ENSG00000091140 DLD
ENSEMBL_homo_sapiens_GENE:ENSG00000091140.15 DLD
HGNC:2898 DLD
KEGG Gene (Homo sapiens):1738 DLD
Monarch:1738 DLD
NCBI Gene:1738 DLD
OMIM:238331 DLD
UCSC:P09622 DLD
Reference Transcript
RefSeq:NM_001289752.1 DLD
RefSeq:NM_001289751.1 DLD
RefSeq:NM_001289750.1 DLD
RefSeq:NM_000108.4 DLD
Other Identifiers
11718108_a_at
11718109_s_at
11718110_x_at
11718111_at
11748212_x_at
11748488_a_at
11749540_x_at
17050300
1738
209095_PM_at
209095_at
230426_PM_at
230426_at
3018702
3018703
3018704
3018707
3018712
3018713
3018714
3018718
3018719
3018720
3018722
3018724
3018725
3018726
3018728
3018729
3018730
3018731
3018732
3018733
36163_at
8135464
A_14_P103503
A_14_P134041
A_23_P111835
A_33_P3344579
GE60491
GO:0000166
GO:0001669
GO:0003824
GO:0004148
GO:0005515
GO:0005634
GO:0005739
GO:0005759
GO:0005773
GO:0005929
GO:0005947
GO:0005967
GO:0006086
GO:0006091
GO:0006120
GO:0006508
GO:0006520
GO:0006790
GO:0007369
GO:0009083
GO:0016491
GO:0016668
GO:0022414
GO:0030154
GO:0031410
GO:0031514
GO:0034604
GO:0036211
GO:0042391
GO:0042995
GO:0043159
GO:0043226
GO:0045240
GO:0045252
GO:0045254
GO:0048240
GO:0048856
GO:0050660
GO:0055086
GO:0106077
GO:1901135
GO:1902493
HMNXSV003043647
Hs.74635.1.A1_3p_at
ILMN_1664577
L13761_rna1_at
PH_hs_0004260
TC07000697.hg
g181574_3p_at
Participates
as a member of
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
DLD:FAD [mitochondrial matrix] (Homo sapiens)
DLD dimer:2xFAD [mitochondrial matrix] (Homo sapiens)
Inferred To
DLD [mitochondrial matrix]
(Bos taurus)
DLD [mitochondrial matrix]
(Caenorhabditis elegans)
DLD [mitochondrial matrix]
(Canis familiaris)
DLD [mitochondrial matrix]
(Danio rerio)
DLD [mitochondrial matrix]
(Dictyostelium discoideum)
DLD [mitochondrial matrix]
(Drosophila melanogaster)
DLD [mitochondrial matrix]
(Gallus gallus)
DLD [mitochondrial matrix]
(Mus musculus)
DLD [mitochondrial matrix]
(Plasmodium falciparum)
DLD [mitochondrial matrix]
(Rattus norvegicus)
DLD [mitochondrial matrix]
(Saccharomyces cerevisiae)
DLD [mitochondrial matrix]
(Schizosaccharomyces pombe)
DLD [mitochondrial matrix]
(Sus scrofa)
DLD [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001276680.1
,
NP_001276681.1
,
NP_001276679.1
,
NP_000099.2
OpenTargets
ENSG00000091140
HPA
ENSG00000091140-DLD
GeneCards
P09622
Ensembl
ENSP00000390667
,
ENST00000205402
,
ENST00000417551
,
ENSP00000387542
,
ENSP00000205402
,
ENSG00000091140
,
ENST00000437604
PRO
P09622
Pharos - Targets
P09622
Orphanet
15871
PDB
5NHG
,
6I4Z
,
1ZY8
,
3RNM
,
6I4U
,
6I4Q
,
6I4P
,
1ZMC
,
7ZYT
,
6HG8
,
6I4R
,
6I4T
,
7PSC
,
5J5Z
,
1ZMD
,
2F5Z
,
6I4S
HMDB Protein
HMDBP00054
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
5
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text