Reactome: A Curated Pathway Database

oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]

Stable Identifier
R-HSA-70241
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
Locations in the PathwayBrowser
Summation

The transfer of a high-energy phosphate bond from GTP to oxaloacetate, to form phosphoenolpyruvate, GDP, and CO2, is catalyzed by cytosolic phosphoenolpyruvate carboxykinase (Dunten et al. 2002). This reaction is irreversible under physiological conditions.

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
phosphoenolpyruvate carboxykinase (GTP) activity of PCK1 [cytosol] PCK1 [cytosol] phosphoenolpyruvate carboxykinase (GTP) activity (0004613)
Orthologous Events
Cross References
Rhea