oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]

Stable Identifier
R-HSA-70241
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol]
Locations in the PathwayBrowser
Summation

The transfer of a high-energy phosphate bond from GTP to oxaloacetate, to form phosphoenolpyruvate, GDP, and CO2, is catalyzed by cytosolic phosphoenolpyruvate carboxykinase (Dunten et al. 2002). This reaction is irreversible under physiological conditions.

Literature References
PubMed ID Title Journal Year
11851336 Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site

Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, GB, Swain, A, Weber, D, Wertheimer, SJ

J Mol Biol 2002
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphoenolpyruvate carboxykinase (GTP) activity of PCK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Reviewed