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Pyruvate metabolism
Stable Identifier
R-HSA-70268
Type
Pathway
Species
Homo sapiens
Synonyms
Cori Cycle (interconversion of glucose and lactate)
ReviewStatus
5/5
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Metabolism (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
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Pyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanine. It can be converted by the pyruvate dehydrogenase complex to acetyl CoA (Reed and Hackert 1990) which can enter the TCA cycle or serve as the starting point for the syntheses of long chain fatty acids, steroids, and ketone bodies depending on the tissue and metabolic state in which it is formed. It also plays a central role in balancing the energy needs of various tissues in the body. Under conditions in which oxygen supply is limiting, e.g., in exercising muscle, or in the absence of mitochondria, e.g., in red blood cells, re-oxidation of NADH produced by glycolysis cannot be coupled to generation of ATP. Instead, re-oxidation is coupled to the reduction of pyruvate to lactate. This lactate is released into the blood, and is taken up primarily by the liver, where it is oxidized to pyruvate and can be used for gluconeogenesis (Cori 1981).
Literature References
PubMed ID
Title
Journal
Year
2188967
Structure-function relationships in dihydrolipoamide acyltransferases.
Reed, LJ
,
Hackert, ML
J Biol Chem
1990
7273846
The glucose-lactic acid cycle and gluconeogenesis
Cori, CF
Curr Top Cell Regul
1981
Participants
Events
ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
(Homo sapiens)
LDH tetramer reduces PYR to LACT
(Homo sapiens)
LDHAL6B reduces PYR to LACT
(Homo sapiens)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
(Homo sapiens)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol
(Homo sapiens)
LDH tetramer oxidises LACT to PYR
(Homo sapiens)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
(Homo sapiens)
MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix
(Homo sapiens)
lipo-PDH decarboxylates PYR to Ac-CoA
(Homo sapiens)
Regulation of pyruvate dehydrogenase (PDH) complex
(Homo sapiens)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH
(Homo sapiens)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT
(Homo sapiens)
Participates
as an event of
Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
Event Information
Go Biological Process
pyruvate metabolic process (0006090)
Orthologous Events
Pyruvate metabolism (Bos taurus)
Pyruvate metabolism (Caenorhabditis elegans)
Pyruvate metabolism (Canis familiaris)
Pyruvate metabolism (Danio rerio)
Pyruvate metabolism (Dictyostelium discoideum)
Pyruvate metabolism (Drosophila melanogaster)
Pyruvate metabolism (Gallus gallus)
Pyruvate metabolism (Mus musculus)
Pyruvate metabolism (Plasmodium falciparum)
Pyruvate metabolism (Rattus norvegicus)
Pyruvate metabolism (Saccharomyces cerevisiae)
Pyruvate metabolism (Schizosaccharomyces pombe)
Pyruvate metabolism (Sus scrofa)
Pyruvate metabolism (Xenopus tropicalis)
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