Galactose catabolism

Stable Identifier
R-HSA-70370
Type
Pathway
Species
Homo sapiens
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The main sources of galactose in the human diet are milk and milk products. The disaccharide lactose from these sources is hydrolyzed in the intestine to its constituent monosaccharides, glucose and galactose. Galactose is metabolized primarily in the liver in a sequence of three reactions that yield one molecule of glucose 1-phosphate per molecule of galactose. First, it is phosphorylated to yield galactose 1-phosphate. Then, galactose 1-phosphate and UDP-glucose react to form UDP-galactose and glucose 1-phosphate, and UDP-galactose undergoes epimerization to form UDP-glucose. In a reaction shared with other pathways, glucose 1-phosphate can be converted into glucose 6-phosphate (Holton et al. 2001; Elsas and Lai 2001).

Literature References
PubMed ID Title Journal Year
11261429 The molecular biology of galactosemia.

Elsas, LJ, Lai, K

Genet Med 2001
  The Metabolic & Molecular Bases of Inherited Disease

Scriver, CR, Beaudet, AL, Sly, WS, Valle, D

  2001
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