PGM:Mg2+ isomerise G1P to G6P

Stable Identifier
R-HSA-70427
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
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Cytosolic phosphoglucomutase 1 (PGM1) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity and its primary physiological in normal tissues in vivo is not clear. Cytosolic glucose 1,6-bisphosphate synthase (PGM2L1) also possesses phosphoglucomutase activity (Maliekal et al. 2007, Veiga-da-Cunha et al. 2008).

Literature References
PubMed ID Title Journal Year
18927083 Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase

Veiga-da-Cunha, M, Vleugels, W, Maliekal, P, Matthijs, G, Van Schaftingen, E

J. Biol. Chem. 2008
7902568 The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination

March, RE, Putt, W, Hollyoake, M, Ives, JH, Lovegrove, JU, Hopkinson, DA, Edwards, YH, Whitehouse, DB

Proc Natl Acad Sci U S A 1993
17804405 Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family

Maliekal, P, Sokolova, T, Vertommen, D, Veiga-da-Cunha, M, Van Schaftingen, E

J Biol Chem 2007
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
phosphoglucomutase activity of PGM:Mg2+ [cytosol]
Physical Entity
Activity
Orthologous Events