GAPDH [cytosol]

Stable Identifier
R-HSA-70428
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
glyceraldehyde-3-phosphate dehydrogenase monomer, glyceraldehyde 3-phosphate dehydrogenase, liver, glyceraldehyde 3-phosphate dehydrogenase, muscle, G3P2_HUMAN, G3P1_HUMAN, Glyceraldehyde 3-phosphate dehydrogenase, liver
Locations in the PathwayBrowser
General

While there are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, there is only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989). Consistent with this conclusion, the homogeneous enzymes purified from various human tissues had indistinguishable physical and immunochemical properties (Heinz and Freimuller 1982), and studies of human erythrocytes of various ages suggested that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

External Reference Information
External Reference
Gene Names
GAPDH, GAPD, CDABP0047, OK/SW-cl.12
Chain
initiator methionine:1, chain:2-335
Other Identifiers
0001850181
0001940184
11754912_x_at
212581_x_at
213453_x_at
217398_3p_x_at
217398_x_at
2347474
2379956
2597
2962139
3290165
3402628
3402629
3402630
3402632
3402635
3402636
3402637
3402638
3402640
3402642
3402643
3402645
3402647
3402648
3402649
3402651
3402652
3402653
3419406
3419414
35905_s_at
3992397
4005331
4005332
4005336
4006736
7953385
AFFX-HUMGAPDH/M33197_3_at
AFFX-HUMGAPDH/M33197_5_at
AFFX-HUMGAPDH/M33197_M_at
GE80009
GO:0000166
GO:0000226
GO:0002376
GO:0003674
GO:0004365
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005635
GO:0005737
GO:0005811
GO:0005829
GO:0005856
GO:0005886
GO:0005975
GO:0006006
GO:0006091
GO:0006094
GO:0006096
GO:0006412
GO:0006417
GO:0006464
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0007010
GO:0007267
GO:0008017
GO:0008092
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0010951
GO:0015031
GO:0015630
GO:0016020
GO:0016241
GO:0016491
GO:0016620
GO:0016740
GO:0017148
GO:0019828
GO:0030234
GO:0031640
GO:0031965
GO:0031982
GO:0032991
GO:0034641
GO:0035605
GO:0035606
GO:0042802
GO:0043226
GO:0043231
GO:0044281
GO:0044403
GO:0048471
GO:0050661
GO:0050715
GO:0050821
GO:0050832
GO:0051287
GO:0051402
GO:0051873
GO:0052501
GO:0055114
GO:0061621
GO:0061844
GO:0070062
GO:0071346
GO:0097452
GO:0097718
GO:1990904
Hs.169476.4.A1_3p_s_at
Hs.169476.5.A1_3p_s_at
ILMN_1343295
ILMN_1802252
ILMN_2038778
PH_hs_0037816
TC12000084.hg
TC12002203.hg
TC16001826.hg
X01677_f_at
Participant Of
Inferred To
Cross References
ZINC - World Drugs
OpenTargets
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
Target Pathogen
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (9)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P00533 EGFR  59 0.785 7
 UniProt:P12004 PCNA  5 0.571 3
 UniProt:Q9UHD2 TBK1  5 0.564 2
 UniProt:P04183 TK1  1 0.553 2
 UniProt:P04626 ERBB2  117 0.553 2
 UniProt:P00558 PGK1  1 0.544 2
 UniProt:P35228 NOS2  3 0.499 8
 UniProt:P00441 SOD1  5 0.499 3
 UniProt:Q60823 Akt2  7 0.499 2
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