alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate

Stable Identifier
R-HSA-70471
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Glucose 6-phosphate is isomerized to form fructose-6-phosphate
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Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).

Literature References
PubMed ID Title Journal Year
13538944 Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.

Tsuboi, KK, Estrada, J, Hudson, PB

J Biol Chem 1958
7989588 The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia

Xu, W, Beutler, E

J Clin Invest 1994
  The Enzymes, 3rd ed

Boyer, PD

  1972
11371164 The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia

Read, J, Pearce, J, Li, X, Muirhead, H, Chirgwin, J, Davies, C

J Mol Biol 2001
  The Enzymes, 3rd ed

Boyer, PD

  1973
Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
glucose-6-phosphate isomerase activity of GPI dimer [cytosol]
Physical Entity
Activity
Orthologous Events