Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate

Stable Identifier
R-HSA-70501
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
Locations in the PathwayBrowser
Summation

The carboxylation of pyruvate to form oxaloacetate, catalyzed by mitochondrial pyruvate carboxylase, is an irreversible and allosterically regulated reaction (Jitrapakdee and Wallace 1999).

Literature References
PubMed ID Title Journal Year
12437512 Expression and characterization of a human pyruvate carboxylase variant by retroviral gene transfer

Carbone, MA, Robinson, BH

Biochem J 2003
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
pyruvate carboxylase activity of pyruvate carboxylase holoenzyme [mitochondrial matrix]
Physical Entity
Activity
This entity is regulated by
Orthologous Events
Reviewed