Reactome: A Curated Pathway Database

Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate

Stable Identifier
R-HSA-70501
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
Locations in the PathwayBrowser
Summation

The carboxylation of pyruvate to form oxaloacetate, catalyzed by mitochondrial pyruvate carboxylase, is an irreversible and allosterically regulated reaction (Jitrapakdee and Wallace 1999).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
pyruvate carboxylase activity of pyruvate carboxylase holoenzyme [mitochondrial matrix] pyruvate carboxylase holoenzyme [mitochondrial matrix] pyruvate carboxylase activity (0004736)
Orthologous Events