Reactome | LDHB [cytosol]

LDHB [cytosol]

Stable Identifier

R-HSA-70503

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

lactate dehydrogenase B, L-lactate dehydrogenase B chain , LDH-B, LDH heart subunit, LDH-H

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07195 LDHB

Gene Names

LDHB

Chain

initiator methionine:, chain:2-334

Reference Genes

BioGPS Gene:3945 LDHB

COSMIC (genes):LDHB LDHB

CTD Gene:3945 LDHB

dbSNP Gene:3945 LDHB

ENSEMBL:ENSG00000111716 LDHB

ENSEMBL_homo_sapiens_GENE:ENSG00000111716.14 LDHB

HGNC:6541 LDHB

KEGG Gene (Homo sapiens):3945 LDHB

Monarch:3945 LDHB

NCBI Gene:3945 LDHB

OMIM:150100 LDHB

Reference Transcript

Other Identifiers

11756099_a_at

16762126

201030_PM_x_at

201030_x_at

213564_PM_x_at

213564_x_at

33819_at

3446869

3446870

3446871

3446874

3446877

3446878

3446882

3446885

3446886

3446887

3446892

3446893

3446896

3446897

3446898

3446899

3945

4013160

43827_s_at

7961693

A_23_P53476

A_33_P3231432

GE80813

GO:0003824

GO:0004457

GO:0004459

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005739

GO:0005743

GO:0005829

GO:0006089

GO:0006090

GO:0016020

GO:0016491

GO:0016616

GO:0019674

GO:0019752

GO:0019900

GO:0042802

GO:0043226

GO:0045121

GO:0051287

GO:0055086

GO:0070062

GO:1990204

HMNXSV003036989

Hs.234489.1.A1_3p_a_at

ILMN_1728132

PH_hs_0029462

TC12001298.hg

X13794_rna1_at

g4557031_3p_x_at

Participates

as a component of

Inferred To

LDHB [cytosol] (Bos taurus)

LDHB [cytosol] (Caenorhabditis elegans)

LDHB [cytosol] (Canis familiaris)

LDHB [cytosol] (Danio rerio)

LDHB [cytosol] (Drosophila melanogaster)

LDHB [cytosol] (Gallus gallus)

LDHB [cytosol] (Mus musculus)

LDHB [cytosol] (Rattus norvegicus)

LDHB [cytosol] (Sus scrofa)

LDHB [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001167568.1, NP_002291.1, NP_001302466.1

OpenTargets

ENSG00000111716

ZINC - Substances

LDHB_HUMAN

ZINC target

P07195

PRO

P07195

PDB

1T2F, 1I0Z, 7DBJ, 7DBK

HPA

ENSG00000111716-LDHB

GeneCards

P07195

Ensembl

ENSG00000111716, ENSP00000379386, ENSP00000229319, ENST00000350669, ENST00000396076

Pharos - Targets

P07195

ZINC - Predictions - Purchasable

LDHB_HUMAN

Orphanet

16345

HMDB Protein

HMDBP03577

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00338 LDHA	2	PolyUb-LDHA [cytosol] (R-HSA-9861549) LDHA [cytosol] (R-HSA-70502)	0.804	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P50542 PEX5	4	p-PEX5 [peroxisomal membrane] (R-HSA-9665182) Ub-p-PEX5 [peroxisomal membrane] (R-HSA-9665183) PEX5 [peroxisomal membrane] (R-HSA-9665164) PEX5 [cytosol] (R-HSA-9033132)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.525	2

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