Reactome | carbamoyl phosphate + ornithine => citrulline + orthophosphate

carbamoyl phosphate + ornithine => citrulline + orthophosphate

Stable Identifier

R-HSA-70560

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

carbamoyl phosphate + ornithine => citrulline + orthophosphate

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial ornithine transcarbamoylase (OTC) catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline (Horwich et al. 1984). The enzyme is a homotrimer (Shi et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
6372096	Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase. Doolittle, RF, Konigsberg, W, Kalousek, F, Kraus, JP, Williams, KR, Fenton, WA, Horwich, AL, Rosenberg, LE	Science	1984
11237854	Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes Tong, L, Tuchman, M, Allewell, NM, Yu, X, Shi, D, Morizono, H	Biochem J	2001