carbamoyl phosphate + ornithine => citrulline + orthophosphate

Stable Identifier
R-HSA-70560
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Mitochondrial ornithine transcarbamoylase (OTC) catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline (Horwich et al. 1984). The enzyme is a homotrimer (Shi et al. 2001).

Literature References
PubMed ID Title Journal Year
11237854 Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes

Shi, D, Morizono, H, Yu, X, Tong, L, Allewell, NM, Tuchman, M

Biochem J 2001
6372096 Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase.

Horwich, AL, Fenton, WA, Williams, KR, Kalousek, F, Kraus, JP, Doolittle, RF, Konigsberg, W, Rosenberg, LE

Science 1984
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ornithine carbamoyltransferase activity of OTC trimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
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