oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]

Stable Identifier
R-HSA-70581
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
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Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer.

Literature References
PubMed ID Title Journal Year
2241899 The amino acid sequence of cytosolic aspartate aminotransferase from human liver

Doyle, JM, Schinina, ME, Bossa, F, Doonan, S

Biochem J 1990
Participants
Input
Output
Participant Of
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Event Information
Reverse Reaction
aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1] (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT1 dimer [cytosol]
Physical Entity
GOT1 dimer [cytosol]
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (0004069)
Orthologous Events
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Dictyostelium discoideum)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Gallus gallus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Plasmodium falciparum)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Xenopus tropicalis)
Cross References
Rhea