oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]

Stable Identifier
R-HSA-70581
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer.

Literature References
PubMed ID Title Journal Year
2241899 The amino acid sequence of cytosolic aspartate aminotransferase from human liver

Doyle, JM, Schinina, ME, Bossa, F, Doonan, S

Biochem J 1990
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea