Reactome: A Curated Pathway Database

aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]

Stable Identifier
R-HSA-70592
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of aspartate and 2-oxoglutarate (alpha-ketoglutarate) to form oxaloacetate and glutamate (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
L-aspartate:2-oxoglutarate aminotransferase activity of GOT1 dimer [cytosol] GOT1 dimer [cytosol] L-aspartate:2-oxoglutarate aminotransferase activity (0004069)
Orthologous Events
Cross References
Rhea