GOT2 dimer deaminates L-Asp

Stable Identifier
R-HSA-70596
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
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Mitochondrial glutamate oxaloacetate transaminase 2 (aspartate aminotransferase 2 - GOT2) catalyzes the reversible reaction of aspartate and 2-oxoglutarate (alpha-ketoglutarate) to form oxaloacetate and glutamate (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

Literature References
PubMed ID Title Journal Year
4052435 The primary structure of mitochondrial aspartate aminotransferase from human heart

Martini, F, Angelaccio, S, Barra, D, Pascarella, S, Maras, B, Doonan, S, Bossa, F

Biochim Biophys Acta 1985
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events