GOT2 dimer deaminates L-Asp

Stable Identifier
R-HSA-70596
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mitochondrial glutamate oxaloacetate transaminase 2 (aspartate aminotransferase 2 - GOT2) catalyzes the reversible reaction of aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) to form oxaloacetate (OA) and glutamate (L-Glu) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.
Literature References
PubMed ID Title Journal Year
4052435 The primary structure of mitochondrial aspartate aminotransferase from human heart

Bossa, F, Maras, B, Barra, D, Pascarella, S, Angelaccio, S, Doonan, S, Martini, F

Biochim Biophys Acta 1985
Participants
Participates
Event Information
Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Cite Us!