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ASNS [cytosol]
Stable Identifier
R-HSA-70597
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Asparagine synthetase (glutamine-hydrolyzing), Glutamine- dependent asparagine synthetase, TS11 cell cycle control protein
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
Expression of ASNS (Asparagine Synthetase) (Homo sapiens)
ASNS [cytosol] (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Expression of ASNS (Asparagine Synthetase) (Homo sapiens)
ASNS [cytosol] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
Expression of ASNS (Asparagine Synthetase) (Homo sapiens)
ASNS [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Aspartate and asparagine metabolism (Homo sapiens)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)
ASNS dimer [cytosol] (Homo sapiens)
ASNS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08243 ASNS
Gene Names
ASNS, TS11
Chain
initiator methionine:, chain:2-561
Reference Genes
BioGPS Gene:440 ASNS
COSMIC (genes):ASNS ASNS
CTD Gene:440 ASNS
dbSNP Gene:440 ASNS
ENSEMBL:ENSG00000070669 ASNS
ENSEMBL_homo_sapiens_GENE:ENSG00000070669.17 ASNS
HGNC:753 ASNS
KEGG Gene (Homo sapiens):440 ASNS
Monarch:440 ASNS
NCBI Gene:440 ASNS
OMIM:108370 ASNS
UCSC:P08243 ASNS
Reference Transcript
RefSeq:NM_001178077.1 ASNS
RefSeq:NM_001673.4 ASNS
RefSeq:NM_183356.3 ASNS
RefSeq:NM_133436.3 ASNS
RefSeq:NM_001178075.1 ASNS
RefSeq:NM_001178076.1 ASNS
Other Identifiers
11716364_s_at
11716365_x_at
11744763_x_at
11748793_a_at
17060061
17125034
205047_PM_s_at
205047_s_at
2564534
2564536
2564537
3062586
3062587
3062588
3062590
3062592
3062593
3062595
3062599
3062600
3062601
3062602
3062605
3062607
3062610
3062611
3062614
3062618
3062619
3062620
3062621
3062622
3096800
3096802
3133689
3133691
3133694
3133698
3133707
36671_at
4053889
440
70493_at
8141150
GE81052
GO:0000166
GO:0000278
GO:0003824
GO:0004066
GO:0005515
GO:0005524
GO:0005829
GO:0006520
GO:0006529
GO:0006541
GO:0006807
GO:0008652
GO:0012501
GO:0016874
GO:0042149
GO:0043066
GO:0045931
GO:0070981
HMNXSV003012730
HMNXSV003051296
ILMN_1796417
ILMN_2398107
M27396_s_at
PH_hs_0026107
TC07001630.hg
g4502258_3p_a_at
Participates
as an output of
Expression of ASNS (Asparagine Synthetase) (Homo sapiens)
as a component of
ASNS dimer [cytosol] (Homo sapiens)
Inferred To
Asns [cytosol]
(Mus musculus)
Homologues of ASNS [cytosol]
(Saccharomyces cerevisiae)
ASNS [cytosol]
(Bos taurus)
ASNS [cytosol]
(Caenorhabditis elegans)
ASNS [cytosol]
(Canis familiaris)
ASNS [cytosol]
(Dictyostelium discoideum)
ASNS [cytosol]
(Gallus gallus)
ASNS [cytosol]
(Plasmodium falciparum)
ASNS [cytosol]
(Rattus norvegicus)
ASNS [cytosol]
(Saccharomyces cerevisiae)
ASNS [cytosol]
(Schizosaccharomyces pombe)
ASNS [cytosol]
(Sus scrofa)
ASNS [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_597680.2
,
NP_001171547.1
,
NP_899199.2
,
NP_001171546.1
,
NP_001171548.1
,
NP_001664.3
OpenTargets
ENSG00000070669
ZINC - Substances
ASNS_HUMAN
ZINC target
P08243
PRO
P08243
PDB
6GQ3
GeneCards
P08243
HPA
ENSG00000070669-ASNS
Ensembl
ENST00000175506
,
ENST00000394308
,
ENST00000444334
,
ENSP00000377846
,
ENSP00000414901
,
ENSP00000406994
,
ENST00000394309
,
ENSP00000377845
,
ENSP00000414379
,
ENSP00000175506
,
ENSG00000070669
,
ENST00000437628
,
ENST00000455086
,
ENSP00000408472
,
ENST00000422745
Pharos - Targets
P08243
ZINC - Predictions - Purchasable
ASNS_HUMAN
Orphanet
22662
HMDB Protein
HMDBP00583
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86WT6 TRIM69
1
TRIM69 [cytosol]
(R-HSA-5688977)
0.666
4
UniProt:Q86WT6-2 TRIM69
0.556
3
UniProt:A2RRH5 WDR27
0.556
3
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