glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

Stable Identifier
R-HSA-70606
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic glutamine synthetase (glutamate-ammonia ligase - GLUL) catalyzes the reaction of glutamate, ammonia, and ATP to form glutamine, ADP, and orthophosphate. The enzyme is a decamer (Krajewski et al. 2008). Mutations in the gene encoding GLUL cause glutamine deficiency in vivo (Haberle et al. 2005).

Literature References
PubMed ID Title Journal Year
16267323 Congenital glutamine deficiency with glutamine synthetase mutations

Häberle, J, Gorg, B, Rutsch, F, Schmidt, E, Toutain, A, Benoist, JF, Gelot, A, Suc, AL, Hohne, W, Schliess, F, Häussinger, D, Koch, HG

N Engl J Med 2005
18005987 Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design

Krajewski, WW, Collins, R, Holmberg-Schiavone, L, Jones, TA, Karlberg, T, Mowbray, SL

J Mol Biol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutamate-ammonia ligase activity of GLUL decamer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea