Reactome: A Curated Pathway Database

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]

Stable Identifier
R-HSA-70613
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial aspartate aminotransferase catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix] GOT2 dimer [mitochondrial matrix] L-aspartate:2-oxoglutarate aminotransferase activity (0004069)
Cross References
Rhea