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PXLP-K69-ODC1 [cytosol]
Stable Identifier
R-HSA-70689
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ODC, ornithine decarboxylase
Locations in the PathwayBrowser for interactor UniProt:Q9UMX2-2 OAZ3
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of polyamines (Homo sapiens)
Regulation of ornithine decarboxylase (ODC) (Homo sapiens)
Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)
PXLP-K69-ODC1 [cytosol] (Homo sapiens)
NQO1 interaction with ODC (Homo sapiens)
PXLP-K69-ODC1 [cytosol] (Homo sapiens)
ornithine => putrescine + CO2 (Homo sapiens)
PXLP-K69-ODC1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
The Metabolic and Molecular Bases of Inherited Disease, 8th ed
Beaudet, AL
,
Scriver, CR
,
Sly, WS
,
Valle, D
2001
External Reference Information
External Reference
UniProt:P11926 ODC1
Gene Names
ODC1
Chain
chain:1-461
Reference Genes
BioGPS Gene:4953 ODC1
COSMIC (genes):ODC1 ODC1
CTD Gene:4953 ODC1
dbSNP Gene:4953 ODC1
ENSEMBL:ENSG00000115758 ODC1
HGNC:8109 ODC1
KEGG:hsa:4953 ODC1
Monarch:4953 ODC1
NCBI Gene:4953 ODC1
OMIM:165640 ODC1
UCSC:P11926 ODC1
Reference Transcript
RefSeq:NM_001287189.1 ODC1
RefSeq:NM_002539.2 ODC1
RefSeq:NM_001287190.1 ODC1
Other Identifiers
1081_at
11752515_a_at
16894402
200790_PM_at
200790_at
2540162
2540163
2540164
2540166
2540167
2540169
2540171
2540172
2540173
2540174
2540175
2540176
2540178
2540180
2540189
2540190
2540191
2540192
2540193
2540194
36203_at
4953
8050240
A_23_P165840
GE59733
GO:0001822
GO:0003824
GO:0004586
GO:0005515
GO:0005575
GO:0005737
GO:0005829
GO:0006520
GO:0006595
GO:0006596
GO:0008283
GO:0008284
GO:0009615
GO:0016829
GO:0016831
GO:0033387
GO:0042176
GO:0042803
GO:0048856
HMNXSV003046623
ILMN_1748591
M33764_at
PH_hs_0025897
TC02001570.hg
g4505488_3p_at
Participates
as a component of
AZIN1 bound OAZ:ODC complex [cytosol] (Homo sapiens)
ODC:NQO1 complex [cytosol] (Homo sapiens)
ODC:OAZ complex [cytosol] (Homo sapiens)
as an input of
NQO1 interaction with ODC (Homo sapiens)
Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)
Inferred To
odc1 [cytosol]
(Danio rerio)
odc1 [cytosol]
(Xenopus tropicalis)
ODC1 [cytosol]
(Canis familiaris)
ODC1 [cytosol]
(Sus scrofa)
PXLP-K69-ODC1 [cytosol]
(Bos taurus)
PXLP-K69-ODC1 [cytosol]
(Caenorhabditis elegans)
PXLP-K69-ODC1 [cytosol]
(Dictyostelium discoideum)
PXLP-K69-ODC1 [cytosol]
(Drosophila melanogaster)
PXLP-K69-ODC1 [cytosol]
(Gallus gallus)
PXLP-K69-ODC1 [cytosol]
(Mus musculus)
PXLP-K69-ODC1 [cytosol]
(Plasmodium falciparum)
PXLP-K69-ODC1 [cytosol]
(Rattus norvegicus)
PXLP-K69-ODC1 [cytosol]
(Saccharomyces cerevisiae)
PXLP-K69-ODC1 [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 69
Coordinate
69
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
Guide to Pharmacology - Targets
1276
OpenTargets
ENSG00000115758
ENSEMBL
ENSG00000115758
,
ENSP00000514634
,
ENSP00000234111
,
ENSP00000514633
,
ENST00000699835
,
ENST00000234111
,
ENST00000443218
,
ENSP00000390691
,
ENST00000699836
,
ENSP00000385333
,
ENST00000405333
ZINC - Substances
DCOR_HUMAN
ZINC target
P11926
ZINC - Biogenic
DCOR_HUMAN
PRO
P11926
PDB
7S3F
,
5BWA
,
2ON3
,
7U6U
,
2OO0
,
1D7K
,
4ZGY
,
7S3G
,
7U6P
ZINC - Metabolites
DCOR_HUMAN
HPA
ENSG00000115758-ODC1
GeneCards
ODC1
Pharos - Targets
P11926
Orphanet
ODC1
ZINC - Predictions - Purchasable
DCOR_HUMAN
HMDB Protein
HMDBP01034
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMX2 OAZ3
1
OAZ3 [cytosol]
(R-HSA-350586)
0.801
7
UniProt:Q9H8Y8 GORASP2
2
p-T222,T225-GORASP2 [Golgi membrane]
(R-HSA-2422965)
GORASP2 [Golgi membrane]
(R-HSA-2422385)
0.781
11
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.718
6
UniProt:Q9UMX2-2 OAZ3
0.556
3
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