Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate (Bledsoe et al. 1997). The active enzyme is a homodimer (Yennawar et al. 2001, 2002). In the body, this enzyme is widely expressed but is especially abundant in muscle tissue.
Yennawar, NH, Conway, ME, Yennawar, HP, Farber, GK, Hutson, SM
Bledsoe, RK, Dawson, PA, Hutson, SM
Yennawar, NH, Dunbar, J, Conway, ME, Hutson, SM, Farber, GK
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