leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]

Stable Identifier
R-HSA-70724
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate (Bledsoe et al. 1997). The active enzyme is a homodimer (Yennawar et al. 2001, 2002). In the body, this enzyme is widely expressed but is especially abundant in muscle tissue.

Literature References
PubMed ID Title Journal Year
12269802 Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms

Yennawar, NH, Conway, ME, Yennawar, HP, Farber, GK, Hutson, SM

Biochemistry 2002
9165094 Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm)

Bledsoe, RK, Dawson, PA, Hutson, SM

Biochim Biophys Acta 1997
11264579 The structure of human mitochondrial branched-chain aminotransferase.

Yennawar, NH, Dunbar, J, Conway, ME, Hutson, SM, Farber, GK

Acta Crystallogr D Biol Crystallogr 2001
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
branched-chain-amino-acid transaminase activity of BCAT2 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events