Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the reaction of isovaleryl-CoA and FAD to form beta-methylcrotonyl-CoA and FADH2 (Finocchiaro et al. 1978; Rhead and Tanaka 1980). Crystallographic studies demonstrated the existene of a tetramer of IVD polypeptides lacking an aminoterminal mitochondrial targeting sequence (Tiffany et al. 1997).
Tiffany, KA, Roberts, DL, Wang, M, Paschke, R, Mohsen, AW, Vockley, J, Kim, JJ
Rhead, WJ, Tanaka, K
Finocchiaro, G, Ito, M, Tanaka, K
© 2021 Reactome