Reactome | MCCC2 [mitochondrial matrix]

MCCC2 [mitochondrial matrix]

Stable Identifier

R-HSA-70769

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

methylcrotonyl-CoA carboxylase beta chain

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Literature References

PubMed ID	Title	Journal	Year
16023992	Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase Holzinger, A, Anslinger, K, Röschinger, W, Roscher, AA, Herrmann, JM, Polanetz, R, Stadler, SC, Meier, S, Mayerhofer, PU	Biochem Biophys Res Commun	2005

External Reference Information

External Reference

UniProt:Q9HCC0 MCCC2

Gene Names

MCCC2, MCCB

Chain

transit peptide:1-22, chain:23-563

Reference Genes

BioGPS Gene:64087 MCCC2

COSMIC (genes):MCCC2 MCCC2

CTD Gene:64087 MCCC2

dbSNP Gene:64087 MCCC2

ENSEMBL:ENSG00000131844 MCCC2

ENSEMBL_homo_sapiens_GENE:ENSG00000131844.17 MCCC2

HGNC:6937 MCCC2

KEGG Gene (Homo sapiens):64087 MCCC2

Monarch:64087 MCCC2

NCBI Gene:64087 MCCC2

OMIM:609014 MCCC2

UCSC:Q9HCC0 MCCC2

Reference Transcript

Other Identifiers

11729236_at

11729237_a_at

16985911

209623_PM_at

209623_at

209624_PM_s_at

209624_s_at

2814643

2814644

2814648

2814649

2814650

2814651

2814655

2814663

2814664

2814666

2814667

2814668

2814669

2814674

2814679

2814682

2814688

2814689

2814690

2814691

2814692

36432_at

64087

8106068

8177601

88457_at

A_14_P122432

GE56317

GE88197

GO:0000166

GO:0002169

GO:0003824

GO:0004485

GO:0005515

GO:0005524

GO:0005739

GO:0005759

GO:0005829

GO:0006520

GO:0006552

GO:0009083

GO:0015936

GO:0016874

GO:0043226

GO:0055086

GO:1901135

GO:1905202

HMNXSV003034390

Hs.167531.0.S2_3p_at

TC05000334.hg

g10934058_3p_a_at

Participates

as a component of

6x(Btn-MCCC1:MCCC2) [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

MCCC2 [cytosol]

Inferred To

MCCC2 [mitochondrial matrix] (Bos taurus)

MCCC2 [mitochondrial matrix] (Caenorhabditis elegans)

MCCC2 [mitochondrial matrix] (Canis familiaris)

MCCC2 [mitochondrial matrix] (Gallus gallus)

MCCC2 [mitochondrial matrix] (Sus scrofa)

mccb [mitochondrial matrix] (Dictyostelium discoideum)

Mccc2 [mitochondrial matrix] (Drosophila melanogaster)

Mccc2 [mitochondrial matrix] (Mus musculus)

Mccc2 [mitochondrial matrix] (Rattus norvegicus)

mccc2 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_071415.1, XP_005248624.1

OpenTargets

ENSG00000131844

HPA

ENSG00000131844-MCCC2

GeneCards

Q9HCC0

Ensembl

ENSP00000507012, ENST00000340941, ENSG00000131844, ENST00000683789, ENSP00000343657

PRO

Q9HCC0

Pharos - Targets

Q9HCC0

Orphanet

16384

HMDB Protein

HMDBP00508

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	5

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