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ADAM8 [plasma membrane]
Stable Identifier
R-HSA-708331
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Disintegrin and metalloproteinase domain-containing protein 8, ADAM8_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q15642 TRIP10
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Fibronectin degradation by ADAM8 (Homo sapiens)
ADAM8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78325 ADAM8
Gene Names
ADAM8, MS2
Chain
signal peptide:1-16, chain:17-824
Reference Genes
BioGPS Gene:101 ADAM8
COSMIC (genes):ADAM8 ADAM8
CTD Gene:101 ADAM8
dbSNP Gene:101 ADAM8
ENSEMBL:ENSG00000151651 ADAM8
HGNC:215 ADAM8
KEGG:hsa:101 ADAM8
Monarch:101 ADAM8
NCBI Gene:101 ADAM8
OMIM:602267 ADAM8
UCSC:P78325 ADAM8
Reference Transcript
RefSeq:NM_001164490.1 ADAM8
RefSeq:NM_001164489.1 ADAM8
RefSeq:NM_001109.4 ADAM8
Other Identifiers
101
11722225_a_at
11748653_x_at
11748684_a_at
11761343_a_at
16719802
205179_PM_s_at
205179_s_at
205180_PM_s_at
205180_s_at
3315052
3315053
3315054
3315057
3315060
3315061
3315062
3315064
3315065
3315066
3315067
3315068
3315069
3315070
3315071
3315072
3315073
3315074
3315075
3315076
3315077
3315078
3315079
3315080
3315081
3315082
3315083
3315084
3315085
3315086
3315087
3315088
3315089
3315091
3315092
3315093
3315094
3315096
3315097
40712_at
7937150
A_24_P300777
D26579_at
GE57140
GO:0000902
GO:0001525
GO:0002102
GO:0002376
GO:0002523
GO:0002675
GO:0002693
GO:0003824
GO:0004222
GO:0004252
GO:0005509
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005886
GO:0006508
GO:0006954
GO:0007155
GO:0007249
GO:0008237
GO:0008270
GO:0009986
GO:0010718
GO:0010954
GO:0016020
GO:0016787
GO:0022407
GO:0022617
GO:0023061
GO:0030198
GO:0031410
GO:0032010
GO:0032127
GO:0032813
GO:0033089
GO:0034987
GO:0035579
GO:0042581
GO:0043226
GO:0043410
GO:0043524
GO:0045089
GO:0045780
GO:0045785
GO:0046872
GO:0048247
GO:0048870
GO:0050714
GO:0050729
GO:0050839
GO:0051044
GO:0051897
GO:0070245
GO:0070820
GO:0070821
GO:0071133
GO:0071456
GO:0098609
GO:0101003
GO:0140096
GO:2000309
GO:2000391
GO:2000406
GO:2000415
GO:2000418
HMNXSV003030105
HMNXSV003043021
Hs.86947.0.S1_3p_a_at
ILMN_1708348
PH_hs_0004883
TC10001783.hg
g4557252_3p_a_at
Participates
as a member of
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
ADAM8 [tertiary granule membrane]
ADAM8 [specific granule membrane]
ADAM8 [ficolin-1-rich granule membrane]
Inferred To
Homologues of ADAM8 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ADAM8 [plasma membrane]
(Drosophila melanogaster)
ADAM8 [plasma membrane]
(Bos taurus)
ADAM8 [plasma membrane]
(Caenorhabditis elegans)
ADAM8 [plasma membrane]
(Canis familiaris)
ADAM8 [plasma membrane]
(Danio rerio)
ADAM8 [plasma membrane]
(Drosophila melanogaster)
ADAM8 [plasma membrane]
(Gallus gallus)
ADAM8 [plasma membrane]
(Mus musculus)
ADAM8 [plasma membrane]
(Rattus norvegicus)
ADAM8 [plasma membrane]
(Schizosaccharomyces pombe)
ADAM8 [plasma membrane]
(Sus scrofa)
unc-71 [plasma membrane]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
1656
ENSEMBL
ENSP00000453043
,
ENST00000485491
,
ENST00000415217
,
ENSP00000453302
,
ENSP00000453855
,
ENST00000445355
OpenTargets
ENSG00000151651
HPA
ENSG00000151651-ADAM8
ZINC - Substances
ADAM8_HUMAN
ZINC target
P78325
PRO
P78325
Pharos - Targets
P78325
ZINC - Predictions - Purchasable
ADAM8_HUMAN
PDB
4DD8
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14598 NCF1
4
p-S345-NCF1 [cytosol]
(R-HSA-9626824)
p-6S-NCF1 [cytosol]
(R-HSA-9626854)
NCF1 [cytosol]
(R-HSA-1222296)
p-6S-NCF1 [phagolysosome]
(R-HSA-1996220)
0.558
2
UniProt:Q5T0N5 FNBP1L
1
FNBP1L [cytosol]
(R-HSA-8867730)
0.558
2
UniProt:Q15642 TRIP10
1
TRIP10 [cytosol]
(R-HSA-195120)
0.558
2
UniProt:P42680 TEC
3
p-Y206,Y519-TEC [cytosol]
(R-HSA-3448741)
TEC [cytosol]
(R-HSA-912712)
p-Y519-TEC [cytosol]
(R-HSA-3448739)
0.558
2
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