alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA

Stable Identifier
R-HSA-70844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Mitochondrial acetyl-CoA acetyltransferase (ACAT1) catalyzes the reaction of alpha-methyl-acetoacetyl-CoA and CoA to form propionyl-CoA and acetyl-CoA. Structural studies have shown the active enzyme to be a tetramer of ACAT1 polypeptides whose aminoterminal 34 residues, a mitochondrial targeting sequence, have been removed (Haapalainen et al. 2007).
Literature References
PubMed ID Title Journal Year
17371050 Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function

Kondo, N, Haapalainen, AM, Fukao, T, Pirilä, PL, Wierenga, RK, Meriläinen, G

Biochemistry 2007
Participants
Participates
Catalyst Activity

acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
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