urocanate + H2O => 4-imidazolone-5-propionate

Stable Identifier
R-HSA-70903
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic urocanate hydratase (UROC1) catalyzes the hydrolysis of urocanate to form 4-imidazolone-5-propanoate. Human UROC1 was first identified in surveys of genes differentially expressed in hepatoblastoma (Yamamda et al. 2004). Recent biochemical and molecular studies of UROC1 protein and cDNA from a patient with urocanic aciduria has confirmed the function of UROC1 in vivo (Espinos et al. 2009).

Literature References
PubMed ID Title Journal Year
15221005 Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

Yamada, S, Ohira, M, Horie, H, Ando, K, Takayasu, H, Suzuki, Y, Sugano, S, Hirata, T, Goto, T, Matsunaga, T, Hiyama, E, Hayashi, Y, Ando, H, Suita, S, Kaneko, M, Sasaki, F, Hashizume, K, Ohnuma, N, Nakagawara, A

Oncogene 2004
19304569 Mutations in the urocanase gene UROC1 are associated with urocanic aciduria

Espinós, C, Pineda, M, Martinez-Rubio, D, Lupo, V, Ormazabal, A, Vilaseca, MA, Spaapen, LJ, Palau, F, Artuch, R

J Med Genet 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
urocanate hydratase activity of UROC1:NAD+ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored