4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+

Stable Identifier
R-HSA-70906
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Cytosolic imidazolonepropionase catalyzes the hydrolysis of 4-imidazolone-5-propanoate to form N-Formimino-L-glutamate. While evidence from many experimental systems indicates that this reaction occurs, existence of the human enzyme is inferred only from high-throughput screening studies (e.g., Yamada et al. 2004).

Literature References
PubMed ID Title Journal Year
15221005 Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

Yamada, S, Ohira, M, Horie, H, Ando, K, Takayasu, H, Suzuki, Y, Sugano, S, Hirata, T, Goto, T, Matsunaga, T, Hiyama, E, Hayashi, Y, Ando, H, Suita, S, Kaneko, M, Sasaki, F, Hashizume, K, Ohnuma, N, Nakagawara, A

Oncogene 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides of AMDHD1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored