N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

Stable Identifier
R-HSA-70920
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic formimidoyltransferase-cyclodeaminase (FTCD) catalyzes the reaction of N-formiminoglutamate and tetrahydrofolate to form glutamate and 5-formiminotetrahydrofolate. The gene encoding the human enzyme has beeen cloned and its sequence can encode a protein homologous the the biochemically characterized porcine protein (Solans et al. 2000; Murley et al. 1993). The function of FTCD in vivo was established by identification of missense mutations that reduce enzyme activity in patients with glutamate formiminotransferase deficiency (Hilton et al. 2003). Human FTCD is inferred to be an octamer by homology to the porcine enzyme (Murley et al. 1993).

Literature References
PubMed ID Title Journal Year
12815595 The molecular basis of glutamate formiminotransferase deficiency

Hilton, JF, Christensen, KE, Watkins, D, Raby, BA, Renaud, Y, de la Luna, S, Estivill, X, MacKenzie, RE, Hudson, TJ, Rosenblatt, DS

Hum Mutat 2003
7901203 The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli.

Murley, LL, Mejia, NR, MacKenzie, RE

J Biol Chem 1993
10773664 Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency.

Solans, A, Estivill, X, de la Luna, S

Cytogenet Cell Genet 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
formimidoyltetrahydrofolate cyclodeaminase activity of FTCD octamer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored