alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate

Stable Identifier
R-HSA-70952
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-aminoadipate and alpha-ketoglutarate to form alpha-ketoadipate and glutamate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).

Literature References
PubMed ID Title Journal Year
18056996 Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia

Rossi, F, Garavaglia, S, Montalbano, V, Walsh, MA, Rizzi, M

J Biol Chem 2008
18056995 Crystal structure of human kynurenine aminotransferase II

Han, Q, Robinson, H, Li, J

J Biol Chem 2008
12126930 Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).

Goh, DL, Patel, A, Thomas, GH, Salomons, GS, Schor, DS, Jakobs, C, Geraghty, MT

Mol Genet Metab 2002
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
2-aminoadipate transaminase activity of AADAT dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored