isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]

Stable Identifier
R-HSA-70967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial isocitrate dehydrogenase IDH3 catalyzes the irreversible reaction of isocitrate and NAD+ to form alpha ketoglutarate, CO2, and NADH + H+. The enzyme is a heteromer containing four polypeptide chains, two IDH3A, one IDH3B, and one IDH3G, and two Mn++ (Dange and Colman 2010). It is activated by ADP (Soundar et al. 2003, 2006; Bzymek and Colman 2007). This is the first of four oxidation reactions in the citric acid cycle, and the first decarboxylation.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
isocitrate dehydrogenase (NAD+) activity of IDH3 complex [mitochondrial matrix]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea