Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA

Stable Identifier
R-HSA-70975
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial citrate synthase dimer catalyzes the irreversible reaction of acetyl-CoA, water, and oxaloacetate to form citrate and coenzyme A. This reaction is the entry point of two-carbon units into the citric acid cycle. The reaction is subject to allosteric regulation. The gene encoding the human enzyme has been cloned (Goldenthal et al. 1998), but the enzyme has not been characterized in detail - its properties are inferred from those of the well-studied homologous pig enzyme (e.g., Morgunov and Srere 1998).

Literature References
PubMed ID Title Journal Year
9792662 Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate

Morgunov, I, Srere, PA

J Biol Chem 1998
9809442 Cloning and molecular analysis of the human citrate synthase gene

Goldenthal, MJ, Marin-Garcia, J, Ananthakrishnan, R

Genome 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
citrate (Si)-synthase activity of CS dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea