(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+

Stable Identifier
R-HSA-70979
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial malate dehydrogenase catalyzes the reversible reaction of malate and NAD+ to form oxaloacetate and NADH + H+ (Luo et al. 2006). This reaction is highly endergonic but is pulled in the direction annotated here when the TCA cycle is operating. Unpublished crystallographic data indicate that the protein is a dimer (PDB 3E04).

Literature References
PubMed ID Title Journal Year
16740313 An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates

Luo, C, Wang, X, Long, J, Liu, J

J Biochem Biophys Methods 2006
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea