tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate

Stable Identifier
R-HSA-71155
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate and glutamate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Scriver, CR, Beaudet, AL, Valle, D, Sly, WS

  2001
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-tyrosine:2-oxoglutarate aminotransferase activity of TAT dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored