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Tryptophan catabolism
Stable Identifier
R-HSA-71240
DOI
10.3180/REACT_916.2
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Tryptophan catabolism (Homo sapiens)
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Tryptophan is catabolized in seven steps to yield aminomuconate. Intermediates in this process are also used in the synthesis of serotonin and kynurenine (Peters 1991).
Literature References
PubMed ID
Title
Journal
Year
1772073
Tryptophan nutrition and metabolism: an overview
Peters, JC
Adv Exp Med Biol
1991
Participants
Events
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
(Homo sapiens)
SLC36A4 transports L-Trp from extracellular region to cytosol
(Homo sapiens)
TDO tetramer dioxygenates L-Trp to NFK
(Homo sapiens)
IDO1 dioxygenates L-Trp to NFK
(Homo sapiens)
IDO2 dioxygenates L-Trp to NFK
(Homo sapiens)
AFMID hydrolyses NFK to L-KYN
(Homo sapiens)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Homo sapiens)
kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
(Homo sapiens)
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic]
(Homo sapiens)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
(Homo sapiens)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine
(Homo sapiens)
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
(Homo sapiens)
2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2
(Homo sapiens)
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
(Homo sapiens)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
(Homo sapiens)
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial]
(Homo sapiens)
Participates
as an event of
Metabolism of amino acids and derivatives (Homo sapiens)
Event Information
Go Biological Process
tryptophan catabolic process (0006569)
Orthologous Events
Tryptophan catabolism (Bos taurus)
Tryptophan catabolism (Caenorhabditis elegans)
Tryptophan catabolism (Canis familiaris)
Tryptophan catabolism (Danio rerio)
Tryptophan catabolism (Dictyostelium discoideum)
Tryptophan catabolism (Drosophila melanogaster)
Tryptophan catabolism (Gallus gallus)
Tryptophan catabolism (Mus musculus)
Tryptophan catabolism (Rattus norvegicus)
Tryptophan catabolism (Saccharomyces cerevisiae)
Tryptophan catabolism (Schizosaccharomyces pombe)
Tryptophan catabolism (Sus scrofa)
Tryptophan catabolism (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000602
Authored
D'Eustachio, P (2005-07-20)
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