Creatine metabolism

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R-HSA-71288
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Pathway
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Homo sapiens
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In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter.

Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body.

Literature References
PubMed ID Title Journal Year
10893433 Creatine and creatinine metabolism

Wyss, M, Kaddurah-Daouk, R

Physiol Rev 2000
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