Creatine metabolism

Stable Identifier
R-HSA-71288
DOI
10.3180/REACT_813.1
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial intermembrane space, cytosol, plasma membrane
ReviewStatus
5/5
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Creatine metabolism
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In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter.

Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body.

Literature References
PubMed ID Title Journal Year
10893433 Creatine and creatinine metabolism

Kaddurah-Daouk, R, Wyss, M

Physiol Rev 2000
Participants
Events
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as an event of
Event Information
Go Biological Process
creatine metabolic process (0006600)
Orthologous Events
Creatine metabolism (Bos taurus)
Creatine metabolism (Canis familiaris)
Creatine metabolism (Danio rerio)
Creatine metabolism (Gallus gallus)
Creatine metabolism (Mus musculus)
Creatine metabolism (Plasmodium falciparum)
Creatine metabolism (Rattus norvegicus)
Creatine metabolism (Saccharomyces cerevisiae)
Creatine metabolism (Schizosaccharomyces pombe)
Creatine metabolism (Sus scrofa)
Creatine metabolism (Xenopus tropicalis)
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