D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate

Stable Identifier
R-HSA-71296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Cytosolic 6-phosphogluconolactonase (PGLS) catalyzes the hydrolysis of D-glucono-1,5-lactone 6-phosphate to form 6-phospho-D-gluconate (Beutler and Kuhl 1985; Collard et al. 1999).

Literature References
PubMed ID Title Journal Year
3932573 Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism

Beutler, E, Kuhl, W

J Lab Clin Med 1985
10518023 Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1)

Collard, F, Collet, JF, Gerin, I, Veiga-da-Cunha, M, Van Schaftingen, E

FEBS Lett 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
6-phosphogluconolactonase activity of PGLS [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea