sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate

Stable Identifier
R-HSA-71334
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TALDO1 transforms sedoheptulose 7-phosphate and GA3P to Fru(6)P and E4P
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sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate
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Dimeric cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-erythrose 4-phosphate and D-fructose 6-phosphate. Protein expressed from the cloned gene has been characterized biochemically and crystallographically (Banki et al. 1994; Thorell et al. 2000) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).

Literature References
PubMed ID Title Journal Year
10869557 The three-dimensional structure of human transaldolase

Thorell, S, Gergely, P, Banki, K, Perl, A, Schneider, G

FEBS Lett. 2000
11283793 Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.

Verhoeven, NM, Huck, JHJ, Roos, B, Struys, EA, Salomons, GS, Douwes, AC, van der Knaap, MS, Jakobs, C

Am J Hum Genet 2001
8300619 Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence

Banki, K, Halladay, D, Perl, A

J Biol Chem 1994
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Event Information
Reverse Reaction
D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity of TALDO1 dimer [cytosol]
Physical Entity
TALDO1 dimer [cytosol]
Activity
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity (0004801)
Orthologous Events
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Canis familiaris)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Danio rerio)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Dictyostelium discoideum)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Gallus gallus)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Mus musculus)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Rattus norvegicus)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Saccharomyces cerevisiae)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Schizosaccharomyces pombe)
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)