Dimeric cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-erythrose 4-phosphate and D-fructose 6-phosphate. Protein expressed from the cloned gene has been characterized biochemically and crystallographically (Banki et al. 1994; Thorell et al. 2000) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).
Thorell, S, Gergely, P, Banki, K, Perl, A, Schneider, G
Verhoeven, NM, Huck, JHJ, Roos, B, Struys, EA, Salomons, GS, Douwes, AC, van der Knaap, MS, Jakobs, C
Banki, K, Halladay, D, Perl, A
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