Reactome | sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate

sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate

Stable Identifier

R-HSA-71334

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TALDO1 transforms sedoheptulose 7-phosphate and GA3P to Fru(6)P and E4P

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sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate

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Dimeric cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-erythrose 4-phosphate and D-fructose 6-phosphate. Protein expressed from the cloned gene has been characterized biochemically and crystallographically (Banki et al. 1994; Thorell et al. 2000) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
10869557	The three-dimensional structure of human transaldolase Thorell, S, Gergely, P, Banki, K, Perl, A, Schneider, G	FEBS Lett.	2000
11283793	Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. Verhoeven, NM, Huck, JHJ, Roos, B, Struys, EA, Salomons, GS, Douwes, AC, van der Knaap, MS, Jakobs, C	Am J Hum Genet	2001
8300619	Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence Banki, K, Halladay, D, Perl, A	J Biol Chem	1994